Subject to the successful signing of the EU Grant Agreement, a call for 12 DC (Doctoral Candidate) positions is open within the context of the Doctoral Network (DN) project SYNSENSO.
The Doctoral Network SYNSENSO "Cell-free synthetic biology for combinatorial biosensor design", funded within the framework of the Marie Skłodowska-Curie Actions (MSCA), follows an interdisciplinary and cross-sectoral approach by bringing together academic and industrial experts from the fields of cell-free synthetic biology and molecular sensor design to develop novel combinatorial biosensors.
Five academic research groups and two industrial partners, coordinated by Technische Universität Darmstadt in Germany, join forces in SYNSENSO to create a mobility and training platform for young scientists by means of cross-site, interdisciplinary research projects. The DCs will work on individual research projects in order to devise new logic circuits in cell-free systems, build novel responsive elements for analyte detection and integrate logic circuits with response elements to build and test next-generation, combinatorial biosensors.
The project offers the DCs research and training excellence in synthetic biology and biosensor design. The partners of SYNSENSO are leading research groups in synthetic biology and sensors design and their research institutes actively promote young researchers. The 5 academic research groups and 7 partners from the private sector join forces in SYNSENSO to create a platform of intersectoral and multidisciplinary mobility and training. To complement the academic and scientific goals of the DCs, the project offers customized research projects, structured interdisciplinary local and network-wide transferable skills training activities, and secondments at top-ranking European universities and industry partners.
The successful candidate will receive a financial package including mobility and family allowance (if applicable), and will be employed according to the rules for Early Stage Researchers in an Marie Skłodowska-Curie Actions Doctoral Network (DN) and the general regulations of each host institution.
The MSCA-DN will cover 3 years of full-time research. Final contract length and extension options depend on the host institution.
Supported researchers must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment.
Mobility Rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the recruiting beneficiary for more than 12 months in the 36 months immediately before their recruitment date.
- MSc, MRes, MEng, or equivalent in Life Science (Biology, Biochemistry, Biophysics, etc), Bioengineering, Physics or a related discipline
- Wet-lab experience, in particular with genetic engineering or molecular biology
- Interested to work in the field of synthetic biology
- Appreciation for interdisciplinary work and proactive drive to collaborate across disciplines
- proficient in English language
Complete applications are written in English; and include a CV, copies of transcripts of any obtained degrees, as well as contact details of two possible referees.
Additionally, applicants should provide a ranked list of preferred DC projects.
Applications should be submitted until 15.08.2022, and sent via e-mail as a single pdf file to firstname.lastname@example.org
The individual DC projects are set to start between 01.09.2022 and 31.03.2023.
Available projects for Doctoral Candidates (please provide a ranked lists of preferred projects):
- DC1 - Cell-free RNA-based logic circuits, Host: Prof. Heinz Koeppl, Technische Universität Darmstadt, Germany
- DC2 - Machine-learning based design and optimization of analyte-responsive ribozymes, Host: Prof. Beatrix Suess, Technische Universität Darmstadt, Germany
- DC3 - CRISPR-based RNA editing tools for cell-free biosensors, Host: Prof. Tom de Greef, Eindhoven University of Technology, Netherlands
- DC4 -Modeling and simulation of cell-free synthetic circuits, Host: Prof. Tom de Greef, Eindhoven University of Technology, Netherlands
- DC5 - Enhanced cell-free lysates with pre-expressed regulators, Host: Prof. Heinz Koeppl, Technische Universität Darmstadt, Germany
- DC6 - Cell-free responsive elements and biosensors for DNA repair enzymes, Host: Prof. Francesco Ricci, Tor Vergata Universita degli Studi di Roma, Italy
- DC7 - RNA-binding proteins for circuit design and detection of viral infection, Host: Dr. Velia Siciliano, Istituto Italiano di Technologia, Naples, Italy
- DC8 - DNA/RNA responsive elements for cell-free biosensors, Host: Prof. Francesco Ricci, Tor Vergata Universita degli Studi di Roma, Italy
- DC9 - Cell-free synthesis of RNA aptamers on a biochip, Host: Dr. Ralf Strasser, Dynamic Biosensors GmbH, Munich, Germany (PhD awarded from TU Darmstadt)
- DC10 - Cell-free responsive elements for antibodies and proteins detection, Host: Dr. Bruna Marini, Ulisse Biomed GmbH, Udine, Italy (PhD awarded from Tor Vergata Universita degli Studi di Roma)
- DC11 - Intein-based logic gates for multiplexed designs, Host: Prof. Karen Polizzi, Imperial College London, UK (will be funded through the UKRI Horizon Europe Guarantee Funding Scheme)
- DC12 - Developing phosphorylation cascades in cell-free circuits, Host: Prof. Karen Polizzi, Imperial College London, UK (will be funded through the UKRI Horizon Europe Guarantee Funding Scheme)