France - Singapore Science and Innovation Lecture Series
START DATE16/01/2020 - 12:00
END DATE16/01/2020 - 13:00
ORGANISEREmbassy of France in Singapore
"From inherited diseases of the immune system to genes (patho)physiology and gene therapy"
About the speaker:
Prof Alain Fischer is a doctor and the Chair of Experimental Medicine at the Collège de France. His main research areas are on the immune deficiency acquired at birth commonly known as the “'bubble boy disease” and the curative approaches with gene therapy.
The immune system is made of myriads of components that play key roles in the control of infection autoimmune diseases, allergy and cancer. The discovery over the last 30 years of more than 400 inherited diseases of the immune system has contributed to decipher key mechanisms of immune responses. This will be illustrated by the study of inherited autoimmune diseases by which at least seven checkpoints controlling reactivity of T and B-lymphocytes to self have been identified.
In some cases, somatic (besides germ-line) mutations have been found causal broadening the potential spectrum of genetic contribution to autoimmune diseases in conjunction with environmental factors.
These advances also led to develop better strategy of targeted intervention. Among them over the last 20 years, gene therapy has been implemented as a strategy to fix the most severe forms of inherited immunodeficiencies. The method is based on gene addition using virus carriers that bring the therapeutic gene into bone marrow cells. The cells, once corrected ex vivo, can give rise to normal lymphocytes in vivo. This has now led to safe and efficacious usage for 3 diseases, while further extension is being considered to treat more genetic diseases of the hematopoietic system, i.e. the building of blood and the immune system.
ADDRESSDuke-NUS Medical School 8 College Road Amphitheatre, Level 2 Singapore, 169857