23/08/2018

Doctoral candidate (PhD-student)

This job offer has expired


  • ORGANISATION/COMPANY
    University of Gdansk
  • RESEARCH FIELD
    Biological sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    11/07/2019 23:00 - Europe/Athens
  • LOCATION
    Poland › Gdańsk
  • TYPE OF CONTRACT
    Other
  • JOB STATUS
    Other
  • OFFER STARTING DATE
    01/10/2019

Project title: Condition-dependent protease activation for targeted proteolysis in the regulation of DNA replication

Project description:

The goal of this project is elucidation how, depending on conditions, proteases are structurally and spatially regulated to degrade essential replication proteins. The research will concentrate on bacterial Lon protease and its phosphate containing cofactors, contributing to the protease activities. By applying in vitro and in vivo experiments, including real-time, single-molecule and single-cell analysis with a variety of Lon proteins, substrates and cofactors, we expect to describe substrate-specific effects on Lon, and relate them to growth conditions. The cutting-edge techniques will be utilized for the description of the structure of Lon complexes. The research on molecular mechanisms of fundamental processes in bacteria is required due to the growing threat arising from the multidrug-resistant bacterial strains. Our goal is to provide data on Lon as a new target for new antimicrobial strategies based on the protease activity control. The project will be conducted with international collaboration of TEAM partners

Key responsibilities include:

1. performing research using biochemical, genetic, molecular biology and computational techniques (independently and in collaboration with other team members)

2. participation in research design and data analysis

3. participation in preparation and writing of manuscripts

4. supervising younger researchers (Master students) involved in the project

5. active participation in lab meetings, departmental seminars and conferences

6. the project may require research stays in TEAM partners laboratories

We offer:

- 24 months of stipend 4 500 PLN stipend/month

- work in an active research team in an excellent scientific environment

- comprehensive cross-disciplinary training in molecular biology, biochemistry, protein evolution and protein structure/function predictions

- participation in scientific seminars and conferences

Selection process

1. Motivation letter (in English)

2. CV (in English)

3. Recommendation letter, preferentially from supervisor of the master project.

Additional comments

Please include in your offer:

“I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
    Chemistry: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

1. Master degree in one of the fields: biotechnology, biology, bioinformatics, chemistry

2. Solid laboratory training in biochemistry, molecular biology, microbial molecular genetics,

3. Training in bioinformatics, genomics, molecular phylogeny will be an additional advantage

4. Ability to communicate fluently in English (spoken and written)

5. Strong motivation to pursue scientific questions, creativity and analytical thinking

Work location(s)
1 position(s) available at
University of Gdansk
Poland
Gdańsk

EURAXESS offer ID: 333878

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