OFFER DEADLINE15/05/2020 23:30 - Europe/Brussels
EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
ORGANISATION/COMPANYUniversity of Luxembourg (application management through Luxinnovation)
DEPARTMENTLCSB / Krüger
The University of Luxembourg (LCSB / Krüger) is interested in hosting a postdoctoral fellow within the Marie Skłodowska-Curie Individual Fellowship programme.
Please note that this opportunity is not a funded positions (yet); it depend on
1. The organization selecting you for continuing the process and
2. A successful proposal written mostly by you (with some input from your host organization in Luxembourg) and submitted before September 9th 2020.
The research is on autophagy-related risk factors in Parkinson’s disease.
The aim of this project is to gain essential knowledge with respect to the contribution of genetic variability of autophagy-related proteins to the pathogenesis of Parkinson’s disease (PD) via (i) elucidation of rare genetic risk variants, (ii) identification of lysosomal phenotypes that contribute to PD pathogenesis and (iii) analysis of their potential suitability as readouts for the identification of novel therapeutic targets.
The task of the Postdoc will be to generate patient-based cellular models for the functional characterization of mitochondrial phenotypes in iPSC-derived neurons related to PD pathogenesis. The outcome of this project will be the identification of PD-related lysosomal risk variants that act in common pathways and their validation as potential targets for future therapeutic approaches, leading to tailored stratified therapies.
- conduct research process from conception to implementation
- develop methodologies and integrate new technologies
- collect, assemble and evaluate research data
- analyses and interpretation of results obtained
- drafting and editing of preliminary research reports
- prepare and submit scientific documents for peer review for publication independently or in collaboration with other researchers
- perform advanced molecular and cellular biological experiments such as cloning, gene-editing (CRISPR), qPCR
- generation of viral expression constructs and transduction of patient based cellular models
- perform various biochemical assays and protein purifications
- generate and differentiate induced pluripotent stem cells (iPSC) into different CNS-related cell types including 3D cultures (organoids)
- development and application of functional readouts for different mitochondrial and neuronal phenotypes
- presenting the results at scientific meetings as posters or talks
- writing scientific publications and grant applications
- PhD in Cellular Biology, Neuroscience, or related discipline
- strong interest in interdisciplinary research and cellular models of neurodegeneration
- track record in research and laboratory work as documented by publications in internationally acknowledged journals
- profound knowledge of molecular genetics, biochemistry and cell biology
- expertise with inducible pluripotent stem cell models for 2D and 3D cultures
- previous experience with CRISPR/Cas9 gene editing desirable
- excellent communication, team-working and interpersonal skills
- previous experience as supervisor of students
- enthusiasm and great commitment to research
- excellent command of the English language
The Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg is a highly dynamic, multilingual and international working environment at campus Belval. The Clinical & Experimental Neuroscience Group, led by Prof Rejko Krueger, creates a translational bridge between fundamental Parkinson’s disease research and the clinic so that prevention, diagnosis and therapy may help patients in Luxembourg and beyond. We are currently looking for an energetic, highly motivated post-doctoral researcher for a collaborative fundamental biology research project in Parkinson’s Disease.
About Marie Skłodowska-Curie Actions Individual Fellowship:
The MSCA IF are postdoctoral fellowships, financed through the European Commission for 2 year positions, covering salary and research costs of the researchers, who can come from anywhere in the world. The evaluation process of these programmes is more about the project and the career development of the candidate, than his/her publication record. The organizations in Luxembourg that want to host such talented researchers include large public research organizations as well as private companies that offer interesting job perspectives after completion of the fellowship.
Minimal eligibility criteria
- Individual: applicant applies together with host institute
- PhD at the deadline or Masters plus 4 years of full time equivalent research experience
- Not working or living in Luxembourg for longer than 12 months before the call deadline
- For rules see here or contact your NCP
How to apply
Please submit your CV to Charles Betz, Advisor - European R&D and Innovation Support at Luxinnovation, until May 15th 2020 and refer to which position(s) you are applying for; you can also send several finetuned CVs if you are interested in multiple positions. Make sure you address the text and requirements mentioned by the respective hosts.
Please note that applications are made through Luxinnovation, your contact point for Horizon 2020 in Luxembourg, before being handed over to the host company.
Luxinnovation, the Luxembourgish Innovation agency and National Contact Point for MSCA, will support both you and your future host institute during your application phase. For all applicants coming to Luxembourg we offer guidance documents, webinars, training in proposal writing and we will review your proposals if you wish so (depending on our availability). In 2019, MSCA IF proposals from Luxembourg had an average success rate of 28.5%, and proposals reviewed by our service 42%.
More information can be found on our website.
- Cellular Biology
The responsibility for the hosting offers published on this website, including the hosting description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.