Marie Skłodowska-Curie Actions

Post-doctoral Research Fellowship: MSCA-IF 2017 at the Department of Stomatology

    01/09/2018 12:30 - Europe/Brussels
    H2020 / Marie Skłodowska-Curie Actions
    Spain, Granada
    International Project Office
    Promotion & Advisory Unit

Professor Francisco Mesa, from the Department of Stomatology at the University of Granada, welcomes postdoctoral candidates interested in applying for a Marie Skłodowska-Curie Individual Fellowships (MSCA-IF) in this university. Applicants must comply with the Mobility Rule (more information in the participant guide: http://sl.ugr.es/097k).

The University of Granada (UGR) was founded in 1531 and is one of the most relevant universities in Spain, having a prominent position in national rankings and being the second Spanish university according to the Shanghai ARWU 2016. It is also one of the leading Spanish Universities in the flied of dentistry.

Research group CTS-583 was founded in 2007 for research in periodontology and dental implantology. It is a joint group funded by the regional government, and formed by dentists and doctors members of the UGR, the Public Health Service private practice clinicians. One of the main research lines if focused in the pathogenesis of the gingival inflammatory process, the effect of genetic polymorphisms in the expression of inflammatory mediators, new therapeutics for the control of periodontal disease and the systemic implications of periodontitis in other cardiovascular, metabolic or immune diseases. The research line on dental implantology has studied the properties of new grafting materials in implantology, the effect of surface characteristics and the development of new implant surfaces, and the study of peri-implant pathology.

Among the diversity of mechanisms that are related to periodontitis pathogenesis, Neutrophil extracellular traps (NETs) represent a quite recent discovery in the neutrophil-related mechanisms of immunity. NETs have been described as a web-like structure composed of decondensed nuclear DNA, histones and antimicrobial peptides. The process of NET formation, called NETosis, is dependent of a variety of agents, and has been related to several of immune-mediated diseases. NETosis has also been hypothesized to play an important role in the pathogenesis of periodontitis, since this process has also been related to auto-immune tissue damage due to an exacerbated response.

Following this hypothesis, our aim is to study the nature of NETs and their role in periodontal diseases through histological and molecular biology techniques. a) Compare the expression of NETs in tissue samples from patients with periodontitis and gingivitis, with samples from healthy patients; b) Explore the relationship between periodontal pathogens and NET production and evasion; c) Identify possible systemic repercussions of oral NETosis.

Research Area:

  • Life Sciences (LIF)

For a correct evaluation of your candidature, please send the documents below to Professor (fmesa@ugr.es):

  • CV
  • Letter of recommendation (optional)