13/09/2017
Marie Skłodowska-Curie Actions

Post-doctoral Research Fellowship: MSCA-IF 2017 at the Department of Physical Chemistry

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  • OFFER DEADLINE
    01/09/2018 12:30 - Europe/Brussels
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • LOCATION
    Spain, Granada
  • ORGANISATION/COMPANY
    International Project Office
  • DEPARTMENT
    Promotion & Advisory Unit
  • LABORATORY
    NA

Professor Ángel Orte, from the Department of Physical Chemistry at the University of Granada, welcomes postdoctoral candidates interested in applying for a Marie Skłodowska-Curie Individual Fellowships (MSCA-IF) in this university. Applicants must comply with the Mobility Rule (more information in the participant guide: http://sl.ugr.es/097k).

The FQM-247 research group (Photochemistry & Photobiology) is a multidisciplinary group with a long time expertise in the use of fluorescence techniques to study biological systems and develop new diagnostics tools. The main research lines of the group are the development of intracellular dye- and nanoparticle-based sensors, and biophysical studies of biomedically relevant problems, such as protein aberrant aggregation into amyloid fibrils. The group has state-of-the-art instrumentation for multi-dimensional fluorescence microscopy, novel single-molecule fluorescence techniques, a fully equipped spectroscopy lab, and cell culture facilities. The group holds many national and international collaborations for additional research projects and networking.

The increase in the life expectancy in Europe and the rest of the developed countries has brought a greater occurrence of cancer. A lot of scientific efforts are in place for the development of novel diagnostics tools and imaging strategies for drug discovery, early diagnostics, and treatment efficacy monitoring. Cancer cells undergo a reprogramming of their metabolic pathways, and recent investigations are hypothesizing the pivotal role of the specific metabo-phenotypes in tumour progression. Profiling of the metabolic phenotype will help in the early diagnostics of tumoural tissue, as well as in drug discovery. Against this background, this proposal will explore the following aspects: unravelling the crucial role of the metabolic reprogramming in cancer cell biology; and the development of a nanotechnological imaging platform for cancer diagnostics and pre-clinical drug screening. To achieve these goals, we will exploit advanced imaging techniques, nanotechnology sensing, and ultrasensitive fluorescence detection to optimise a multiplex imaging platform, capable of performing cellular metabolic profiling. This will require the simultaneous determination of the glucose consumption rates and the intra-mitochondrial pH, to distinguish between normal oxidative phosphorylation and altered aerobic glycolysis cellular states. In order to overcome the drawbacks of all the previous imaging methods for intracellular sensing, we will take advantage of advanced, multidimensional fluorescence lifetime imaging microscopy (FLIM), and long-lifetime, quantum dot-based nanosensors, designed to respond specifically to the aimed analytes inside live cells. This proposal has the potential to give new, important insights into cancer cell function and diagnostics.

Research Area:

 

  • Chemistry (CHE)
  • Life Sciences (LIF)

For a correct evaluation of your candidature, please send the documents below to Professor (angelort@ugr.es):

  • CV
  • Letter of recommendation (optional)