Marie Skłodowska-Curie Actions

Post-doctoral Research Fellowship: MSCA-IF 2017 at the Department of Histology

    01/09/2018 12:30 - Europe/Brussels
    H2020 / Marie Skłodowska-Curie Actions
    Spain, Granada
    International Project Office
    Promotion & Advisory Unit

Professor Miguel Alaminos, from the Department of Histology at the University of Granada, welcomes postdoctoral candidates interested in applying for a Marie Skłodowska-Curie Individual Fellowships (MSCA-IF) in this university. Applicants must comply with the Mobility Rule (more information in the participant guide: http://sl.ugr.es/097k).

The Tissue Engineering Group of the University of Granada (CTS-115) is one of the reference research groups in Europe in the area of Tissue Engineering and Advanced Therapies. The group has several research lines and patents related to the development and characterization of human bioartificial tissues for clinical use, including the cornea, skin, oral mucosa, ureter, nerve, cartilage and other tissues and organs. For that purpose, the research group has developed several biocompatible biomaterials based on fibrin, agarose, collagen, magnetic nanoparticles, microspheres and tissue decellularization and has described several transdifferentiated cell sources for use in tissue engineering. Bioengineered tissues generated by the group have been evaluated ex vivo and in vivo at the histological, histochemical, genetic, epigenetic, optical and biomechanical levels as part of the preclinical quality controls required for clinical translation. Some of these organs are currently generated in GMP facilities of the Granada University Hospitals and have been grafted in patients included in some Advanced Therapies clinical trials. In fact, the group is pioneer in the clinical evaluation of complex three-dimensional organs created in the laboratory, and previous clinical experiences in cornea and skin reached high worldwide impact.

Development of Tissue Engineering allowed the recent generation of artificial tissues that could contribute to the treatment of a number of diseases for which an effective solution is not currently available. Generation and characterization of functional artificial tissues is highly dependent on the availability of efficient high-tech biomaterials and scaffolds. The project will be focused on designing and characterizing novel smart bioactive tissue-like structures for future clinical use. These artificial tissues could have potential medical impact for the surgical treatment of numerous diseases with high social impact such as skin burns, intestinal, biliary or pancreatic fistulae bone defects and urethral stenosis. Novel tissues will be based on previous knowledge and technology designed by the research group in order to elaborate an advanced therapies pharmaceutical product for clinical use. Natural fibrin-agarose-collagen biomaterials used in clinical trials carried out by the research group will be modified using state-of-the-art nanotechnological approaches (nanostructuration, magnetic nanoparticles and nano-polymeric particles) and will incorporate alternative cell sources as bioactive agents in order to obtain a more efficient therapeutical product able to contribute to the treatment of the above-mentioned diseases. One of the advantages of this approach is the possibility of designing personalized tissue models using autologous cells and fibrin biomaterials obtained from the own patient, and smart models with tunable three-dimensional and geographical structure and shape.

Research Area:

  • Life Sciences (LIF)

For a correct evaluation of your candidature, please send the documents below to Professor (malaminos@ugr.es):

  • CV
  • Letter of recommendation (optional)