26/02/2018
Marie Skłodowska-Curie Actions

Post-doctoral position at University of Granada: Apply for an Athenea3i-2018 Research Fellowship at the Department of Inorganic Chemistry


  • OFFER DEADLINE
    01/09/2018 13:30 - Europe/Brussels
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions COFUND
  • LOCATION
    Spain, Granada
  • ORGANISATION/COMPANY
    International Research Projects Office
  • DEPARTMENT
    Promotion and Advisory Unit
  • LABORATORY
    NA

Professor Manuel Sánchez Polo, from the Department of Inorganic Chemistry at the University of Granada, welcomes postdoctoral candidates interested in applying for an Athenea3i Research Fellowship in 2018 at this University. The information about the Fellowship conditions, how to apply, Eligibility Criteria, Selection Process, Evaluation Process, etc. is available in https://athenea3i.ugr.es/. Please note that applicants must comply with the Eligibility Criteria (https://athenea3i.ugr.es/?page_id=23).  

Brief description of the institution:

The University of Granada (UGR), founded in 1531, is one of the largest and most important universities in Spain. It serves more than 60000 students per year, including many foreign students, as UGR is the leader host institution in the Erasmus program. UGR, featuring 3650 professors and more than 2000 auxiliary personnel, offers a total of 75 degrees through its 112 departments and 28 centers.

UGR is also a leading institution in research, located in the top 5/10 of Spanish universities by a variety of ranking criteria, such as national R&D projects, fellowships awarded, publications, or international funding. UGR is one of the few Spanish Universities listed in the Shanghai Top 500 ranking (http://www.arwu.org/), and it is also well recognized for its web presence (http://www.4icu.org/top200/).

Internationally, we bet decidedly by our participation in the calls of H2020, both at partner and coordination. For the duration of the Seventh Framework Programme, the UGR has obtained a total of 66 projects, with total funding of 17.97 million euros, and for H2020, until 2015, more than 25 projects with total funding of more than 6 million euros. Our more than 3,000 researchers are grouped into 365 research groups covering all scientific fields and disciplines.

Brief description of the Centre/Research Group

The Carbon Materials research group carries out its activities at the Department of Inorganic Chemistry of the University of Granada. With a team of 15 people and 80 research projects done or in development, it possesses a wide research experience in the fields of porous materials and heterogeneus catalysis, with special dedication concerning environment. My research background is focused on the chemistry of solid surfaces and interfaces, carbon materials as adsorbents or catalyst on enviromental remediation of waters. I have published more than 100 articles in international journals and conferences and several book chapters (https://orcid.org/0000-0002-7802-6505) related to the materials characterization and its application in water treatments and catalysis. We are working in a new research area focused on the development of carbon nanoparticles for cancer therapy and diagnosis.

Project description

Skin cancer rate increases at an alarming rate worldwide. In our country, during the last years, an increase of 38% has been observed from the AEDV. Nearly 150.000 newly diagnosed cases are reported every year. During 2016, 11.380 patients developed basal cell carcinoma (BCC), 17.500 developed squamous cell carcinoma (SCC) and 4000 patients suffered from the most dangerous variety, cutaneous malignant melanoma. Despite major efforts are focus on prevention and early detection (initiatives as EUROMELANOMA 2017, a practical guide published by the AEDV to inform the population) once it is diagnosed surgical excision is the most effective treatment used for local and nonmetastatic skin cancers while the use of anticancer drugs is necessary in case of metastasis. The rapid developments in nanotechnology during the past two decades as drug nanocarriers make it possible to use in cancer therapy. Thus, the main objective of this project consist of the development of new chemotherapy drugs nanocarriers with lower toxicity and easy transdermal/topical delivery thanks to a magnetic core. This magnetic core also allows triggered drug delivery responsive to an external stimuli (magnetic field) targeting tumor areas and improving the efficiency of the drugs. Finally the presence of Ag(0) can emit strong visible fluorescence for melanoma imaging, helping with a theranostic effect of this novel material.  Thus, the specific objetives can be described as: 

  1. Synthesis of magnetite nanoparticles core covered by a silver shell
  2. Adition of Doxorubicin (DOX), paclitaxel (PTX) and docetaxel (DTX) through the adition of a reducing agent or using UV radiation 
  3. Characterization and selection of suitable materials
  4. Study of controlled drug delivery
  5. Citotoxicity and in vivo study

Research Area

  • Life Sciences (LIFE)

For a correct evaluation of your candidature, please send the documents below to Professor Manuel Sánchez Polo (mansanch@ugr.es):

  • CV
  • Letter of recommendation (optional)