Marie Skłodowska-Curie Actions

phD Fellowship, Horizon 2020 Marie Skłodowska-Curie Project CARTNET – Structural Biology

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    31/01/2018 17:00 - Europe/Brussels
    H2020 / Marie Skłodowska-Curie Actions
    Spain, Valencia
    Instituto de Biomedicina de Valencia (CSIC)
    Molecular Crystallography Unit

Two-component systems, composed of sensor histidine kinases and effector response regulators, are the predominant mechanism in bacterial sensing, signaling, pathogenicity and antibiotic resistance development. Therefore, the proteins forming theses systems represent an exciting novel target for antibiotic development, an area of urgent medical need.

As part of the Marie Curie European Training Network, CARTNET, a PhD Fellowship position is available to focus on the rational design of novel inhibitors of bacterial sensor histidine kinases with antibiotic activity. The project will Involve a multidisciplinary approach that includes (but is not limited to) molecular biology, biochemistry and biophysical techniques. The structural characterization of the drug-histidine kinase complexes by X-ray crystallography will be the starting point for the design of new inhibitors with greater potency and selectivity, which will be analysed biochemically and biophysically by the candidate.

The candidate will improve the potency and anti-bacterial activity of the initial hits using computer-aided design techniques by a secondment in Oxford Drug Design (UK) and/or will determine the antibacterial activity of the improved inhibitors against a large panel of target pathogens and strains by a secondment in Wageningen University (The Netherlands). In addition, the project will involve interaction and collaboration with CARTNET Fellows from other disciplines and training events.

The overall aim of CARTNET is to train young researchers in Europe to address serious and global problems of antibiotic resistance.

Please apply with a curriculum vitae and covering letter, detailing your motivation in applying for this project. Applications should be received by 31-Jan-2018 and sent to: amarina@ibv.csic.es Questions regarding the post can be sent to the same address.

Eligibility criteria

  1. Early Stage Researchers (ESRs) must, by definition, have less than 4 years research experience at the date of signing the contract (measured from the date of award for their most recent taught degree).
  2. ESRs must not yet have a PhD or be enrolled on one.
  3. ESRs must not have resided, or undertaken employment (main activity) within the host country of the ESR for which they apply for more than 12 months in the last 3 years immediately prior to the reference recruitment date (1st March 2018).
  4. Eligibility according to EU regulations.
  5. Masters-level degree in Biosciences or a related discipline.
  6. Excellent command of the English language (oral, writing).
  7. Demonstrable ability to conduct research in line with the objectives of the project.
  8. Evidence of planning skills to contribute to the research project.
  9. Ability to work alone and also as part of a multidisciplinary team.

Willingness to travel within Europe.