Nantes Université MSCA-PF 2023 - hosting offer at l'institut du thorax

Céline Marionneau research officer from the Thorax institute at Nantes Université is looking for postdoctoral candidates interested in applying for a Marie Skłodowska-Curie Postdoctoral Fellowships (MSCA-PF) in 2023.

Keywords
Nav1.5 channels, cardiac electrophysiology, arrhythmias, phosphorylation, interacting proteins, proteomics

What is a MSCA Postdoctoral Fellowship?
MSCA Postdoctoral fellowships support the career development of researchers for enhancing their individual competence diversification in terms of skills at multidisciplinary level and intersectoral experience. The MSCA-PF grant provides a competitive salary plus mobility and family allowances if applicable, as well as research, training and networking costs. This call to interest concerns the European Postdoctoral Fellowships (12 to 24 months of duration in Europe + optional placement in private sector in Europe of 6 months). For more information: MSCA-PF

Team description
The team II of l’institut du thorax studies the molecular and cellular mechanisms involved in the physiological regulation of cardiac membrane excitability, and how these mechanisms are altered in inherited or acquired cardiac disease. More specifically, the group of Céline Marionneau is focusing on better understanding the role of post-translational modifications, including phosphorylation and interacting proteins, in regulating the expression and functioning of the Nav1.5 voltage-gated Na+ channel.This group has performed several elegant proteomic and electrophysiological analyses of the cardiac Nav1.5 channels over the last 10 years, and is now internationally recognized for the identification of more than 50 phosphorylation sites on the cardiac Nav1.5 channels.

Research project
The project to be developed by the postdoctoral fellow will focus on determining the signaling pathways, kinases, phosphatases, phosphorylation sites and interacting proteins involved in regulating the expression and functioning of the cardiac Nav1.5 channel. The approach will use mass spectrometry-based proteomic analyses coupled with manual and high-throughput automated patch-clamp of primary cultures of cardiomyocytes, pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and HEK-293 cells. The specific involvement of these mechanisms in disease will then be investigated in the context of several inherited or acquired cardiac arrhythmias.
 

What are the eligibility criteria?
Candidates must hold a PhD at the call deadline (13 Sept. 2023) and have 8 years maximum of full-time research experience after the PhD.
“Mobility rule”: candidates must NOT have resided or carried out their main activity (work, studies, etc.) in France for more than 12 months in the 36 months immediately before the call deadline.Candidates can be from any nationality.
Although not an eligibility criterion, a good track record is recommended.
 

What’s in it for me?
1. Selected candidate will have access to online training programme and one-to-one proposal preparation sessions with our experienced European Officers.
2. Selected candidate will have the opportunity to come to Nantes for two days in the beginning of July to meet his supervisor and to start working on the writing of the project. The grant awarded for this stay will cover travel, hotel and subsistence expenses for 2 days and 2 nights (up to 1000€ for the EU countries and up to 2000€ for the non-EU countries). Nantes Université does not cover the visa fees.
 

I’m interested. What should I do?
If you are interested and have the required background, apply by sending the application form  to Céline MARIONNEAU (celine.marionneau@univ-nantes.fr) and the European office (europe.drpi@univ-nantes.fr)

More information on the dedicated webpage.

Registration for this scheme does not imply automatic funding. Applications will be examined in the light of the MSCA PF evaluation criteria, both by your potential supervisor and by the experienced European Officers. No application will be considered after April 14th but we encourage you to apply as soon as possible as they will be evaluated as they arise.The short-stay grant will be distributed among the selected candidate within the limits of the available budget.

You should expect feedback for your application by 15 May.

Brief description of Nantes Université
Nantes Université is a higher education and research institution created in 2022. This new institution has adopted a new University model unprecedented in France by bringing together a university, a university hospital (CHU de Nantes), a technology research centre (IRT Jules Verne), a public scientific and technological institute (Inserm) and higher education establishments (Centrale Nantes, École des Beaux-Arts Nantes Saint-Nazaire, École d’Architecture de Nantes).
Nantes Université is a sustainable and committed institution and one of the driving forces behind societal development. With a global and outward-looking culture, it promotes innovativeness and openness: open science, open research, open education, open innovation. Nantes Université has received the HR Excellence in Research Award and is already involved in various European projects, notably MSCA actions.