05/05/2021
Marie Skłodowska-Curie Actions

MSCA-PF: Joint application at the University of Granada. Department of Physiology

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  • OFFER DEADLINE
    02/09/2021 14:30 - Europe/Brussels
  • EU RESEARCH FRAMEWORK PROGRAMME
    HE / MSCA
  • LOCATION
    Spain, Granada
  • ORGANISATION/COMPANY
    International Research Projects Office
  • DEPARTMENT
    Promotion and Advisory Unit
  • LABORATORY
    NA

Professor Rosa Escames, from the Department of Physiology at the University of Granada, welcomes postdoctoral candidates interested in applying for a Marie Skłodowska-Curie Postdoctoral Fellowships (MSCA-PF) in 2021 at this University. Please note that applicants must comply with the Mobility Rule (more information about the 2020 call: http://sl.ugr.es/0aNV, the 2021 call is not yet open).

Brief description of the institution:

The University of Granada (UGR), founded in 1531, is one of the largest and most important universities in Spain. With over 60.000 undergraduate and postgraduate students and 6.000 staff. UGR offers a total of 89 degrees, 110 master’s degrees and 28 doctoral programmes through its 123 departments and 27 centers. Consequently, the UGR offers one of the most extensive and diverse ranges of higher education programmes in Spain.

The UGR has awarded with the "Human Resources Excellence in Research (HRS4R)", which reflects the UGR’s commitment to continuously improve its human resource policies in line with the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers. UGR is also a leading institution in research, located in the top of Spanish universities by a variety of ranking criteria, such as national R&D projects, fellowships awarded, publications, or international funding. UGR is one of the few Spanish Universities listed in the Shanghai Top 500 ranking - Academic Ranking of World Universities (ARWU) (http://sl.ugr.es/0bsW). The UGR is amongst the 201-300 first universities of the world, between 2nd-5th position of Spanish universities and number 1 in the Andalusian Region in the Shanghai Top 500 ranking. Specialties at UGR that stand out are Library & Information Science (position 32) and Food Science & Technology (position 36). Moreover, the UGR is also situated amongst the first 100 universities in Mining & Mineral Engineering between (76th-100th position), in Mathematics (between 76th-100th position) and in Hospitality & Tourism Management (between 76th-100th position). The edition of the ARWU places the UGR in 201-300th position in the world and as the 4th highest ranked University in Spain, reaffirming its position as an institution at the forefront of national and international research.

Additionally, the UGR has 8 researchers at the top of the Highly Cited Researchers (HCR) list in Computer Sciences & Engineering (position 101-150). It is also well recognized for its web presence (http://sl.ugr.es/0a6i), being positioned at 43th place in the top 200 Universities in Europe.

Internationally, we bet decidedly by our participation in the calls of the Framework Programme of the European Union. For the duration of the last two Framework Programmes, the UGR has obtained a total of 67 projects, with total funding of 18.029 million euros, and for H2020, 118 projects with total funding around 29.115 million euros.

Brief description of the Centre/Research Group:

I’m Professor at the University of Granada and the Director of the Research Group CTS-101: Intercell Communication. We have been studied the antioxidant effects of melatonin and the identification of the mitochondria as the main target of melatonin. Recently, our activity has focused on studies of the oncostatic activity of melatonin, and on the adverse effects of radio and chemotherapy. We have four international patents on melatonin in the last five years, we have carried out three clinical trials, and one Start Up called Pharmamel. S.L. We are part of the Cost MitoEagle action (EU - OC-2015-2-19984), Member of the CIBER of Fragility and Healthy Aging (CIBERfes) (CB/10/00238) and Member of the Unit of Excellence for the Study of Aging Disorders (UNETE - UCE-PP2017-05). Technical skills and competences in our Group are: Molecular skills (protein, RNA and DNA quantification, protein, RNA and DNA extraction from cells and tissue, PCR, western blots, …); Crispr-cas9 techniques; Mitochondrial respiration analysis (Oroboros and Seahorse); Fluorometric and spectrophotometric techniques; Cytometer skills, HPLC and UPLC; Clock genes rhythms; Cell culture skills (stable cell lines and primary cells culture); mice and zebrafish manipulation; Generation of xenografts and orthograph mice models; Histology, etc. The Group is formed by 22 researches. We have published more than 150 papers; Nº Doctoral Thesis directed in the last 10 years = 27; Google Scholar Total citations =8455; average appointments / year in the last 5 years = 756; total posts in the first quartile (Q1) = 74; h-index = 53.

Project description:

Our research group has shown that melatonin induces a shift to an aerobic mitochondrial metabolism in tumor cells. Melatonin enhances mitochondrial function and ROS production, reducing the ATP synthesis. The main objective of this project is to determine whether melatonin overcomes multidrug resistance associated with the overexpression of ATP-driven transmembrane efflux pumps and to evaluate new formulations of melatonin, developed by nanobiotechnology, to increase its bioavailability in the tumor. To do this, we will investigate the connections between ABC transporter P-gp, mitochondrial function and cisplatin (CDDP)/paclitaxel resistance. We will use the CDDP/paclitaxelresistant cells KBChR- 8-5-11, the drug-resistant cells CAL-27 and SCC9 and cells that are genetically modified for the Pgpencoding ABCB1 gene using CRISPR/Cas9 technology. We will evaluate the effects of different melatonin formulations to overcome CDDP and paclitaxel resistance in a mouse xenograft model of drug-resistant head and neck cancer, as well as mouse orthotopic models and patientderived xenograft models. We will evaluate tumor characteristics by NMR and micro- PET/CT using the routine procedures used with oncological patients and in clinical trials; full mitochondrial function including oxygen consumption, together with other relevant bioenergetic parameters will be measured using Oroboros O2k high-resolution respirometry; P-gp analysis by western blot, PCR of ABCB1 gene, efflux activity of P-gp and drugs levels into cancer cells. Apoptosis, proliferation, differentiation, histology, electronic microscopy, among other techniques will be studied in cancer cells; hemogram and biochemical parameters, as well as cytotoxicity in healthy organs, will also be evaluated.

Research Area:

  • Life Sciences (LIFE)

For a correct evaluation of your candidature, please send the documents below to Professor Rosa Escames (gescames@ugr.es):

  • CV
  • Letter of recommendation (optional)

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