25/03/2020
Marie Skłodowska-Curie Actions

MSCA-IF: Joint application at the University of Granada. Department of Pharmacology.

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  • OFFER DEADLINE
    01/07/2020 10:00 - Europe/Brussels
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • LOCATION
    Spain, Granada
  • ORGANISATION/COMPANY
    International Research Projects Office
  • DEPARTMENT
    Promotion and Advisory Unit
  • LABORATORY
    NA

Professor Ahmad Agil, from the Department of Pharmacology at the University of Granada, welcomes postdoctoral candidates interested in applying for a Marie Skłodowska-Curie Individual Fellowships (MSCA-IF) in 2020 at this University. Please note that applicants must comply with the Mobility Rule (more information: http://sl.ugr.es/0aNV).

Brief description of the institution:

The University of Granada (UGR), founded in 1531, is one of the largest and most important universities in Spain. The UGR has been awarded with the "Human Resources Excellence in Research (HRS4R)", which reflects the UGR’s commitment to continuously improve its human resource policies in line with the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers. The UGR is also a leading institution in research, located in the top 5/10 of Spanish universities by a variety of ranking criteria, such as national R&D projects, fellowships awarded, publications, or international funding.

UGR is one of the few Spanish Universities listed in the Shanghai Top 500 ranking (http://sl.ugr.es/0aw0). The Academic Ranking of World Universities (ARWU) places the UGR in 268th position in the world and as the 4th highest ranked University in Spain, reaffirming its position as an institution at the forefront of national and international research. From the perspective of specialist areas in the ARWU rankings, the UGR is outstanding in Documentation (ranked in the 36th in the world) or Food science technology (ranked 37th in the world), Mathematics and Computer Science (ranked among the top 76-100 in the world).

The UGR has 4 researchers at the top of the Highly Cited Researchers (HCR) list in the Computer Science area. With regard to broader subject fields, the UGR is ranked in 45th position in the universities worldwide in the discipline of Engineering. It is also well recognized for its web presence (http://sl.ugr.es/0a6i) taking 36th place in the top 200 Universities in Europe. Internationally, we bet decidedly by our participation in the calls of the Framework Programme of the European Union. For the duration of the last two Framework Programmes, the UGR has obtained a total of 66 projects, with total funding of 18.02 million euros, and for H2020, 80 projects with total funding around 20.6 million euros.

Brief description of the Centre/Research Group

Our research group is focusing in brown adipose tissue a promising therapeutic target for obesity and diabetes: role of melatonin and bioactive ingraients. We have recently demonstrated that chronic oral melatonin administration to Zücker diabetic fatty (ZDF) rats induces browning of inguinal white adipose tissue, i.e., “beige” depots, which have thermogenic properties. We previously demonstrated that melatonin improves mitochondrial respiration, and reduces the oxidative status and susceptibility to apoptosis in white and beige adipocytes. These melatonin effects help to prevent mitochondrial dysfunction and thereby to improve obesity-related metabolic disorders such as diabetes and dyslipidemia of ZDF rats. Our Team is a pioneer and is reflected in impact of our publications publications. The Team Leader is Dr. Agil has completed his degree and a PhD degree in Pharmacy from University of Granada, Spain and postdoctoral studies from both Southwestern Medical Center and Harvard Medical School, USA. Professor Agil is the director of a multidisciplinary-international research group melatonin role in obesity and diabetes. He has published more than 60 papers in reputed journals and has been serving as section Editor of the Journal of Archive of Medical Sciences, an editorial board member of reputed journals and acted as review of several Journals. He has trained 4 Ph.D. and 14 Master D. students and 5 postdoctoral fellows from numerous countries.

Project description

Obesity is a pandemic out of control in developed countries worldwide. Its leadership on the risk of morbidity and mortality conveys an enormous social and economic burden. In addition, the search for effective and safe drugs for its control has failed. Some of natural products active ingradeints, have antioxidant properties. Studies have shown that it could have an anti-obesogenic effect that would involve an increase in basal energy expenditure, suggesting a thermogenic effect. Those bioactive nutrients, in addition to stimulating growth and thermogenic activity of brown adipose tissue, could induce the appearance of "brown-like" adipocyes in areas of the white adipose tissue with termogenic properties similar to those of brown adipocytes. Moreover, some data suggest that those active gradients could shape the gut microbiota. Our aim is to clarify the molecular and transcriptional mechanisms that regulate de novo formation and/or recruitment of beige adipocytes in white adipose tissue, as well as those that control organular functionality (mitochondrion and endoplasmic reticulum) in adipose tissue and the kidney in vitro and in vivo. The ultimate goal of the project is to support the potential use of melatonin for the treatment of human obesity and associated complications such as diabetisity.    

Research Area

Life Sciences (LIFE)

For a correct evaluation of your candidature, please send the documents below to Professor Ahmad Agil (aagil@ugr.es):

  • CV
  • Letter of recommendation (optional)

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