OFFER DEADLINE02/06/2020 17:00 - Europe/Athens
EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
ORGANISATION/COMPANYUniversitat de Barcelona
DEPARTMENTDpt. of Inorganic and Organic Chemistry / Dpt. of XX PHARMACY, IN2UB
Are you a postdoctoral researcher thinking about your next career move? The Marie Sklodowska-Curie (MSCA) Individual Fellowships are a great option if you are an experienced researcher looking to give your career a boost by working abroad.
Group and project information
Project: Water soluble Iron oxide nanoparticles for drug delivery
Iron oxide nanoparticles (NPs) can be readily prepared by well-known methods as monodisperse, crystalline nanoparticles. By controlling the conditions, the major phase in these nanoparticles is the magnetic oxide magnetite, Fe3O4. The properties of iron oxide NPs make them excellent candidates for medical applications: Fe is an essential element and iron oxides can be readily metabolized or assimilated by the organism, thus iron oxide NPs lack the toxicity often related to heavy metals. The fact that they are magnetic can be exploited for targeting specific sites in the organism using a magnetic field that is not harmful. A procedure for preparing water soluble iron oxide NP with hyaluronic acid (NP-HA) has been designed in the GMMF
Cancer therapy with PPRH hairpins. PolyPurine Reverse Hoogsteen hairpins are a new kind of gene silencing molecules developed in our laboratory. They consist of two strands of DNA linked by 5 thymidines. Each strand of that DNA is formed by polypurines and bind to each other by Hoogsteen bonds. These hairpins bind to polypyrimidine tracks present in the genomic DNA inhibiting transcription and splicing thus causing a decrease in gene expression. Therefore, this genomic tool can be used to decrease the expression of genes that are overexpressed in certain diseases, such as cancer.
In this project you will work in a multidisciplinary environment. The main goal is a complete a study of the functionalization of NP-HA with a PPRH hairpin in order to obtain hybrid nanoobjects suitable for delivering the hairpin to the target. The final aim is to be able to deliver therapeutic molecules such as PPRHs using Iron oxide NPs for efficient targeted cancer therapy.
In the project you will optimize the synthesis of the hybrid system and assess the toxicity of the delivery vehicle (NP-HA) and of the functionalized system NP-HA-PPRH.
- experience with synthesis and the functionalisation and characterization of (iron oxide) nanoparticles would be an asset
- experience in cytotoxicity studies would be an asset
- Good (to excellent) writing skills in English (experience in writing publications would be a plus).
- ability to work in an interdisciplinary research environment
Required Languages: English Good to excellent
Eligibility Criteria: Described in the Guide for Applicants
Support for applicants
The International Research Projects Offfice at the University of Barcelona offers support to applicants (eligibility check, info sessions, feedback on the draft proposal) and has recently launched a Mentoring programme specifically designed for MSCA applicants (subject to availability)
Required Documents/Selection process:
- Curriculum Vitae (mail subject: MSCA postdoctoral candidature; email to be sent: firstname.lastname@example.org; email@example.com)
- Two recommendation letters
- Possibility of an interview
Expressions of interest with required documents must be submitted no later than June, 2 2020.
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