18/02/2021
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Beatriu de Pinós programme (BP2020). Nucleic Acids Chemistry Group (NAC). IQAC-CSIC

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  • OFFER DEADLINE
    01/03/2021 18:00 - Europe/Brussels
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions COFUND
  • LOCATION
    Spain, Barcelona
  • ORGANISATION/COMPANY
    IQAC

THE RESEARCH CENTER

The Institute for Advanced Chemistry of Catalonia (IQAC) belongs to the Spanish National Research Council (CSIC), the largest public research institution in Spain and the third among Europe’s largest research organisations.

The IQAC is located in Barcelona and it was created with the mission to perform multidisciplinary research of excellence in both basic and applied chemical sciences with the main purpose of improving the quality of life.

The research carried out at IQAC is based on the application of chemical approaches to address and solve societal challenges, mainly those related to human health, the sustainability of chemical processes and products, and the needs for novel materials for different applications. In this regard, the research programs carried out in our institute are aimed at:

  • the development of methods and strategies for the synthesis of molecules of high added value (Methods & Strategies)
  • the discovery of chemical and molecular entities of therapeutic, biological and biomedical interest (Tools & Hits)
  • the study of molecules with surfactant properties, including synthesis, biophysical studies and applications (Surfactants)
  • the generation and use of nanobiotechnology knowledge for the prevention, diagnostic and treatment of diseases (Nanomedicine).

Administratively, the research groups at IQAC are organized in two departments: Biological Chemistry, and Surfactants and Nanobiotechnology. Moreover, research is complemented with a range of diverse scientific and technical platforms (including cell culture and animal facility), which offer their capabilities to both internal and external users.

 

THE RESEARCH GROUP

Nucleic Acids Chemistry Group (NAC)

Supervisors: Ramon Eritja and Carme Fàbrega

Contact: ramon.eritja@iqac.csic.es

Web page:

Keywords: DNA, RNA, oligonucleotides synthesis, antisense, DNA nanotechnology, drug delivery systems

 

Research lines

The research group has more than thirty years of experience in Nucleic Acid Chemistry. The main objective of the group is gaining a better understanding of novel nucleic acids by chemical modification with the goal to evaluate their efficacy in antisense and RNA interference therapies and also to the delivery of nucleic acid antimetabolites. The group maintains an extensive network of international and national collaborations.

 

Projects description

Structural properties of non-canonical structure and nucleic acids conjugates. The project undertakes the chemical modification of Triplex, G-Quadruplex and i-Motif to study its physico-chemical properties and structural stability. In addition, with the design of specific ligands and nucleic acids conjugates with structural and biological relevance.

Therapeutic oligonucleotides. The project is aims the synthesis of antisense DNA, small interfering RNA, siRNA microRNA with improve nuclease stability for gene silencing efficacy and selectivity (reduce off-target effects) for cell delivery.

DNA nanotechnology (biomedical and bio-sensing applications). We develop nucleic acid molecules designed for the assembly of nanomaterials and biosensor systems for detecting biologically relevant DNA and RNA molecules and for the delivery of cytotoxic drugs.

 

OUR HOSTING OFFER

The IQAC is looking for excellent postdoctoral researchers from any country in the world interested in applying for the Beatriu de Pinós BP2020 call to carry out a 3-year research project in an unbeatable working environment.

To be eligible, the candidate must:

  • Hold a doctoral degree (PhD obtained between 1st January 2013 and 31th December 2018)*
  • At least 2 years of postdoctoral experience outside Spain
  • Have not worked or lived in Spain for more than 12 months in the last 3 years before the deadline.

*Some exceptions apply (see the call text)

Selected candidates will receive help and support from the research coordinator and from our projects department during proposal preparation.

 

If you are interested, please send a CV and a motivation letter explaining your research interest and background by 1st March 2021 to the supervisor indicating Beatriu de Pinós BP2020 call in the subject.

Disclaimer:

The responsibility for the hosting offers published on this website, including the hosting description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.