Outline

Applications are currently being accepted for a 3 year PhD project examining the role of inflammation and altered protein metabolism in the context chronic liver disease at Western Sydney University Blacktown and the Westmead Institute for Medical Research. The project will be conducted in the research group of Professor Golo Ahlenstiel and will remain open until a suitable candidate is found.

Chronic inflammation and altered protein metabolism caused by infection, alcohol, fat or autoimmune disease not only drive progression to end-stage scarring, a state called liver cirrhosis, but also subsequent chronic liver failure and hepatic decompensation with high liver-related mortality. Various markers have been associated with hepatic decompensation, but it remains ill understood what actually initiates the event and how such markers relate to short and long-term survival.

This project aims what to clarify how chronic inflammation and altered protein metabolism contribute to disease progression and activity and clinical severity in advanced liver disease using human samples and mouse models. We will utilise cutting edge genomics, primary cell culture, flow cytometry and/or CyTOF as well as molecular biology techniques. This study will identify new biomarkers predicting clinical outcomes and new targets for therapeutic intervention.

What is funded

• Domestic students will receive a tax-free stipend of $30,000 per annum to support living costs, supported by the Research Training Program (RTP) Fee Offset.
• International students will receive a tax-free stipend of $30,000 per annum to support living costs. Those with a strong track record will be eligible for a tuition fee waiver.

Duration

3 years

Eligibility

We welcome applicants from a range of backgrounds, that possess laboratory experience and a background in medical/health science and/or molecular biology. In particular, the project is suitable for candidates with strong interests in the immunology of chronic hepatic and gastrointestinal disease

The successful applicant should:

• hold qualifications and experience equal to one of the following (i) an Australian First Class Bachelor (Honours) degree, (ii) Research Master’s degree, or (iii) equivalent overseas qualifications.

• demonstrate strong academic performance in subjects relevant to immunology and disease.
• understand of the importance of identifying the mechanisms of disease in order to generate novel treatments and interventions.
• be willing to learn novel lab based and analytical techniques using a variety or advanced instrumentation.
• be enthusiastic and highly motivated to undertake further study at an advanced level.
• International applicants must also meet English language proficiency.