31/01/2018

PhD in Pharmacy: Synthesis and characterization of biodegradable polymer nanotubes for applications in focal drug delivery to the brain

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  • ORGANISATION NAME
    Cardiff University
  • ORGANISATION COUNTRY
    United Kingdom
  • FUNDING TYPE
    Funding
  • DEADLINE DATE
    31/03/2018
  • RESEARCH FIELD
    Formal sciences
    Professions and applied sciences
  • CAREER STAGE
    First Stage Researcher (R1) (Up to the point of PhD)

Outline

We have previously synthesized soft and flexible polymer nanotubes and shown that they release anti-cancer drugs for a period of one month.

These early studies have proved the concept that high aspect ratio materials with their unique properties can allow long-term drug release. Unlike carbon nanotubes, these polymer nanotubes have shown no toxicity in in vitro cultures showing that they could be a promising material to use as a focal delivery device.

This project seeks to expand on this work and create the first completely biodegradable nanotubes. The end goal is to use these nanotubes to deliver a range of compounds to glioblastoma multiforme.

By working on this project you will learn a range of techniques including the synthesis of the precursor polymers (polymer synthesis), synthesis and characterization of polymer nanotubes (materials science plus a range of analytical techniques), analysis of the drug loading and release, toxicity analysis (cell culture).

The aim is to make a non-toxic, biodegradable drug delivery device that can deliver three compounds to the tumor for a six-week duration.

 

What is funded

Full UK/EU tuition fees and a Doctoral stipend matching UK Research Council National Minimum.

Duration

3 years

Eligibility

Open to all UK/EU students without further restrictions