ORGANISATION NAMECardiff University
ORGANISATION COUNTRYUnited Kingdom
RESEARCH FIELDFormal sciencesProfessions and applied sciences
CAREER STAGEFirst Stage Researcher (R1) (Up to the point of PhD)
We have previously synthesized soft and flexible polymer nanotubes and shown that they release anti-cancer drugs for a period of one month.
These early studies have proved the concept that high aspect ratio materials with their unique properties can allow long-term drug release. Unlike carbon nanotubes, these polymer nanotubes have shown no toxicity in in vitro cultures showing that they could be a promising material to use as a focal delivery device.
This project seeks to expand on this work and create the first completely biodegradable nanotubes. The end goal is to use these nanotubes to deliver a range of compounds to glioblastoma multiforme.
By working on this project you will learn a range of techniques including the synthesis of the precursor polymers (polymer synthesis), synthesis and characterization of polymer nanotubes (materials science plus a range of analytical techniques), analysis of the drug loading and release, toxicity analysis (cell culture).
The aim is to make a non-toxic, biodegradable drug delivery device that can deliver three compounds to the tumor for a six-week duration.
What is funded
Full UK/EU tuition fees and a Doctoral stipend matching UK Research Council National Minimum.
Open to all UK/EU students without further restrictions