13/12/2017

PhD in Medicine: Integration of genetic and functional data to identify drug targets and enhance risk prediction

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  • ORGANISATION NAME
    Cardiff University
  • ORGANISATION COUNTRY
    United Kingdom
  • FUNDING TYPE
    Funding
  • DEADLINE DATE
    09/02/2018
  • RESEARCH FIELD
    Natural sciences
  • CAREER STAGE
    First Stage Researcher (R1) (Up to the point of PhD)

Outline

Integrating brain expression and protein-protein interaction data with genomic data, identified a network of immune-related genes implicated in Alzheimer’s disease (AD) susceptibility.

We propose to use functional data from relevant tissues to refine this network and incorporate the results into measures of genetic disease risk prediction. In particular we will seek to incorporate epigenomic data into gene and pathway based analyses.

The student will incorporate the results of these analyses into standard measures of genetic risk (polygenic risk scores) and investigate the extent to which this improves risk prediction.

What is funded

UK/EU tuition fees and Doctoral stipend matching UK Research Council National Minimum

Duration

3 years

Eligibility

You will hold or expect to achieve a First or Upper Second Class degree in a relevant area (eg neuroscience, psychology, anatomy, physiology, natural sciences). As this is a training doctorate, previous research experience is not essential.