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PhD student position

Mossakowski Medical Research Institute, Polish Academy of Sciences The Human Resources Strategy for Researchers
22 Nov 2022

Job Information

Organisation/Company
Mossakowski Medical Research Institute, Polish Academy of Sciences
Research Field
Neurosciences
Neurosciences » Neurobiology
Biological sciences
Biological sciences » Biology
Researcher Profile
First Stage Researcher (R1)
Country
Poland
Application Deadline
Type of Contract
Temporary
Job Status
Full-time
Hours Per Week
40
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Reference Number
ZNTK-111-7/2022
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

Department of Neurotoxicology, Mossakowski Medical Research Institute Polish Academy of Sciences is recruiting PhD student to the NCN OPUS 21 project entitled „Role of GAB glutaminase in glioblastoma” (2021/41/B/NZ5/01883).

Leader: dr hab. Monika Szeliga

The project:

A growing body of evidence suggests that GAB glutaminase acts as a tumor suppressor. Our previous studies clearly indicate that: i) glioblastoma (GBM), the most malignant glial tumor, lacks GAB; ii) transfection of GBM cells with a GAB sequence inhibits their survival, proliferation, migration, and sensitizes them to oxidative stress and temozolomide, a first-line chemotherapeutic agent for GBM.

The main objective of this project is to elucidate the molecular determinants of tumor-suppressive properties of GAB observed in GBM cells and examine the influence of GAB transfection on the phenotype of GBM cells in in vivo settings. The main hypothesis of this project, supported by preliminary results and data from the literature, is that transfection with a GAB sequence suppresses malignant phenotype of GBM cells by modulation of the transcriptome/miRNome and/or proteome of these cells. Results from this project will enrich the existing knowledge about the role of GAB in GBM cells.

Location and duration:

Department of Neurotoxicology, Mossakowski Medical Research Institute Polish Academy of Sciences in Warsaw, 02-106 Poland, Pawinskiego Street 5 (http://www.imdik.pan.pl).

PhD student will be recruited for 40 months with the stipend according to NCN recommendations (introduced by the Resolution of the NCN Council No. 25/2019 of March 14, 2019 (uchwala69_2019_ang.pdf), starting March 2023.

Requirements:

  • M.Sc. or equivalent in biology, biotechnology, medicine or other related subjects
  • Knowledge of cell and molecular biology methods (including cell culture, cell assays, DNA/RNA techniques, qPCR, western blotting, immunocytochemistry)
  • Very good command of English and practice in scientific writing/presentation of scientific data in English
  • Communication skills, openness to new challenges, very good organization of laboratory work, creative and analytical thinking
  • Experience in small animal research will be highly appreciated

Requirements

Research Field
Neurosciences
Education Level
Bachelor Degree or equivalent
Research Field
Biological sciences
Education Level
Bachelor Degree or equivalent
Languages
ENGLISH
Level
Good
Research Field
NeurosciencesNeurosciences » Neurobiology
Years of Research Experience
1 - 4
Research Field
Biological sciences » BiologyBiological sciences
Years of Research Experience
1 - 4
Internal Application form(s) needed
how_to_apply_zntk.111.7.2022.pdf
English
(167.04 KB - PDF)
Download

Additional Information

Work Location(s)

Number of offers available
1
Company/Institute
Mossakowski Medical Research Institute, Polish Academy of Sciences
Country
Poland
City
Warsaw
Postal Code
02-106
Street
5 Pawinskiego Street
Geofield

Where to apply

E-mail
mszeliga@imdik.pan.pl

Contact

City
Warsaw
Website
Street
5 Pawinskiego Street
Postal Code
02-106