30/08/2022
European Research Council

Post-doctoral researcher (PostDoc) on an ERC-COG research program investigating the molecular biology of novel siderophore-antibiotic conjugate uptake and release

This job offer has expired


  • ORGANISATION/COMPANY
    Institut Pasteur de Lille
  • RESEARCH FIELD
    Biological sciencesOther
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    30/09/2022 23:00 - Europe/Brussels
  • LOCATION
    France › Lille
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    36
  • OFFER STARTING DATE
    01/11/2022
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / ERC
  • REFERENCE NUMBER
    864832

OFFER DESCRIPTION

Passionate about fighting bacteria and antibiotic discovery?

 

A post-doctoral research position investigating the molecular biology and potential of novel siderophore conjugates (ERC-COG research project ANTBIOCLICKS), is now open in the Hartkoorn Lab located at the Institut Pasteur of Lille. The Hartkoorn lab’s primary focus is on innovation in antibiotic drug discovery and development.

The frightening increase in antibiotic drug resistance is threatening global healthcare as we know it. To this extent, the World Health Organisation that has classes M. tuberculosis and a number of Gram-negative infections as the highest priority for novel R&D strategies. A major obstacle to drug discovery programs is to design inhibitors that can efficiently enter into bacteria. One such strategy is by coupling antibiotic molecules to siderophores that are taken up by the bacteria for iron acquisition. In this project, ANTIBIOCLICKS, new bioinspired siderophore conjugates are being developed for such a stealth delivery system targeting M. tuberculosis, A. baumannii, E. coli, P. aeruginosa and K. pneumonia. The particular focus for this research project will be to define the potential of new bioinspired siderophore conjugates for antibiotic delivery into A. baumannii and P. aeruginosa, and to clearly define the mechanisms of sideromycin uptake and intracellular decoupling.

 

Applicants should hold a PhD in a relevant biology field (molecular biology, pharmacology, pharmacy, microbiology etc). Applicants are expected to have a strong background in bacterial research including specific experience with A. baumannii and P. aeruginosa. Candidates need be competent in bacterial genetic engineering, understand of how antibiotics function, and have experience with imaging techniques for bacteria. Previous experience in siderophores research is a bonus. The candidate will need to work as part of a multidisciplinary team and communicate in English. Written English and manuscript writing must be excellent.

 

Starting date

As soon as possible

Contact

Interested applicant should contact Ruben Hartkoorn (ruben.hartkoorn@inserm.fr), with the subject: Postdoc Application AntiBioClicks_Bio_2022, and provide a CV and a cover letter (English).

More Information

Work location(s)
1 position(s) available at
Institut Pasteur de Lille
France
Lille
1, rue du professeur Calmette

EURAXESS offer ID: 830513

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