01/06/2022

PhD Position in Chemistry and biotechnology, Early stage researcher


  • ORGANISATION/COMPANY
    Tallinn University of Technology
  • RESEARCH FIELD
    ChemistryOrganic chemistry
    ChemistryOther
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    30/06/2022 23:00 - Europe/Brussels
  • LOCATION
    Estonia › Tallinn
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/09/2022

OFFER DESCRIPTION

Tallinn University of Technology, School of Science, Department of Chemistry and biotechnology offers a 4-year PhD position in the field of chemistry and biotechnology.

Proposed doctoral thesis topic: "Synthesis and application of conformationally flexible multifunctional organocatalysts".

Supervisor: Professor Tõnis Kanger

Abstract

The PhD project will focus on the design, synthesis and application of multifunctional enantiomerically pure organocatalysts. New catalysts possess several halogen bonding, hydrogen bonding and Lewis basic sites mimicking active sites of enzymes.

Description

Asymmetric catalysis has become a major tool for the synthesis of enantiomeric compounds and at present catalytic reactions have surpassed the auxiliary-based approaches. The project deals with asymmetric organocatalysis that is one of the top ten emerging technologies in chemistry listed by IUPAC experts in 2019. New multifunctional catalysts that consist of halogen bonding and hydrogen bonding Lewis basic or carboxylic site will be designed and synthesized. Coupling of these catalytic moieties with amino acids is a tool for the construction of the chiral skeleton of the catalyst. The modular nature of amino acids allows developing different chiral environment of the catalyst mimicking enzymes. Conformational flexibility of enzymes often leads to the preorganization of the active site (due to stabilizing non-covalent interactions) and remarkable rate accelerations and selectivity is achieved. To address the problem of the conformational rigidity vs flexibility of the catalyst quantum chemical calculations will be used. The optimal structure of the catalyst will be calculated and according to obtained results, new catalysts will be synthesized. Thus, the project connects basic organic chemistry, asymmetric synthesis, supramolecular and computational chemistry. Synthesized catalysts will be applied in various reactions leading to precursors or intermediates of biologically active compounds. The PhD student will gain extensive experience in asymmetric synthesis and analysis.

More Information

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

  • PhD candidates must have a master’s degree in a relevant scientific discipline and a strong interest in organic chemistry.
  • The successful candidate will be a highly motivated and proactive individual with excellent communication skills.
  • Strong experience in organic synthesis, analytical (NMR, MS) and chromatographic methods (HPLC, GC) needed for characterizing synthesized compounds are desirable.

Specific Requirements

The information for the PhD admission is available at TalTech’s web-page: https://www.taltech.ee/en/phd-admission

Required application documents:

  • CV
  • Motivation letter
  • Degree certificates
  • Copy of the passport

Map Information

Job Work Location Personal Assistance locations
Work location(s)
1 position(s) available at
Tallinn University of Technology
Estonia
Tallinn
12618
Akadeemia tee 15

Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R)

Know more about it at Tallinn University of Technology

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EURAXESS offer ID: 793233

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