ORGANISATION/COMPANYInstitute of Physics, Polish Academy of Sciences, Warsaw
RESEARCH FIELDPhysics › Biophysics
RESEARCHER PROFILERecognised Researcher (R2)
APPLICATION DEADLINE31/01/2022 23:00 - Europe/Brussels
LOCATIONPoland › 02-668 Warsaw
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE01/02/2022
REFERENCE NUMBERJob ID: #JOB 56/2021
The postdoctoral researcher will join the Division of Theoretical Physics at the Institute of Physics, Polish Academy of Sciences, to participate in the research project on “Biomolecular condensates of galectin-3” supported by the National Science Centre. The postdoctoral researcher will perform molecular dynamics simulations of galectin-3 condensates – both in aqueous solutions and at lipid membranes – using the MARTINI coarse-grained model.
Galectins are proteins involved in many biological functions, including immune responses, cell migration and signaling. The multiple biological functions of galectins stem from their interactions with diverse glycoproteins and glycolipids. In mammals, the galectin family consists of 15 members. Galectin-3 is unique within this protein family because of its peculiar molecular architecture. Galectin-3 has been reported to be involved in numerous intra- and extracellular processes, including endocytosis.
The molecular mechanisms underlying the galectin-3-dependent endocytosis remain elusive. Very recently, however, galectin-3 has been demonstrated to undergo liquid-liquid phase separation (LLPS), which sheds new light on how this protein can perform its biological functions. The objectives of the project are: (i) to explore the intra- and inter-molecular interactions that drive the LLPS of galectin-3, (ii) to give a detailed description of the molecular architecture of galectin-3 condensates in aqueous solutions and at membrane surfaces, and (iii) to explain the molecular mechanisms underlying the membrane bending and endocytic pit formation by the galectin-3 biomolecular condensates. The postdoctoral researcher will contribute towards achieving the objectives of the project using molecular dynamics methods within the framework of the MARTINI coarse-grained model.
- PhD in physics or a related branch of science;
- communicativeness and good command of spoken and written English;
- diligence at work and consistency in achieving results;
- knowledge of statistical physics;
- good knowledge of numerical methods in molecular biophysics and/or chemistry;
- experience with molecular dynamics simulations of biological macromolecules;
- experience with the GROMACS package and the MARTINI force field will be considered strong assets.
Application deadline: January 31, 2022. Applications after the deadline are not considered.
• PhD diploma or an explanation of when one is expected
• Curriculum Vitae • List of publications • Motivation letter • Contact data (e-mail) to at least two potential referees • Consent to process your personal data (expressed on the form attached to this announcement).
All materials should be submitted in electronic form to the address: email@example.com with Job ID in the subject.
Main research field: Physics
Sub Research Field: Theoretical Biophysics
Career Stage: PhD in physics or a related discipline obtained no earlier than in 2015
Institute of Physics of the Polish Academy of Sciences
Research Profile (details): Recognized Researcher (R2)
Type of Contract: Temporary
Appointment: 30 months
Salary: 10000 PLN per month (before taxes)
More information can be obtained from Bartosz Różycki (email: firstname.lastname@example.org). Please make contact.
EURAXESS offer ID: 724403
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