12/11/2021

Research engineer position in radiobiology

This job offer has expired


  • ORGANISATION/COMPANY
    Université de Caen Normandie
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    24/11/2021 23:00 - Europe/Brussels
  • LOCATION
    France › Caen
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/12/2021
  • REFERENCE NUMBER
    State-Region Planning Contracts

OFFER DESCRIPTION

We are looking for a highly motivated and focused individual to join Aria laboratory in Cimap, Caen, France, for an engineer position under supervision of Dr. François Chevalier, CEA/Cimap.

 

Project description

New treatment combinations, including hadron therapy and targeted therapy, have improved the outcome of cancer treatment. It has been suggested that tumor-initiating cells, also called cancer stem cells (CSCs), are responsible for relapse and therapy failure. CSCs have unlimited capacity to self-renew and differentiate to all cell populations present in the original tumors. These two fundamental properties make these cells responsible for tumor growth and recurrences thus a critical and important target for cancer therapy. CSCs seems to be protected from radiation-induced damage by the hypoxic microenvironment and by number of intrinsic mechanisms such as elevated DNA damage response, effective DNA repair and elevated antioxidant system.

The present project focuses in the three potential biological pathways underlying radio-resistant namely DNA repair, hypoxia/tumour microenvironment and anti-oxidative capacity. These pathways will be studied in different inhibition combinations in at least two cancer stem cell models, at the origin of radioresistant tumors, and the effect of hadron will be explored.

More Information

Required Research Experiences

  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4
  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    4 - 10

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good
Work location(s)
1 position(s) available at
Université de Caen Normandie
France
Caen
CS 14032
Esplanade de la Paix 14032 CAEN CEDEX

EURAXESS offer ID: 706705

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