The Human Resources Strategy for Researchers

PhD Student: Novel antimicrobial strategy development for medical implants

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    Academic Medical Center (AMC)
    Medical sciences
    First Stage Researcher (R1)
    Recognised Researcher (R2)
    21/11/2021 23:59 - Europe/Brussels
    Netherlands › Amsterdam


About your role
We are looking for a motivated and enthusiastic PhD candidate for the recently started project DARTBAC: Dutch Antimicrobial Resistance Technology development and Biofilm Assessment Consortium. The performance of novel antimicrobial technologies involving biomaterial applications will be evaluated in ex vivo and in vivo systems, in particular in mouse models of bone or subcutaneous implant infection. You will tailor these models for testing of release systems/coatings with (novel) antimicrobial agents such as synthetic antimicrobial and antibiofilm peptides (SAAPs), photosensitizers, or bioactive glass for their antimicrobial capacity. Subsequently, you will assess the efficacy of novel systems in these models against multi-drug resistant bacteria. Since antimicrobial efficacy is also critically dependent on the host immune response, detailed studies will be performed to analyse cellular immune responses, inflammatory mediators such as cytokines and their regulation. In this way, novel antimicrobial biomaterials can be developed based on the so-called ‘safe-by-design’ principle.
You can find more information on the DARTBAC consortium on the DARTBAC website.

The project
The DARTBAC project aims to develop novel antimicrobial technologies, not based on antibiotics, to target infection prevention and eradication in all tissues and on implant (biomaterial) surfaces. In this way we aim to help prevent the rise of the anti-microbial resistance, which will constitute a major societal impact. DARTBAC is an interdisciplinary consortium consisting of academic partners, technical universities, university medical centres, small and large medical device companies with antimicrobial technologies and knowledge institutes.

More Information


Our offer

  • A jump start to your career in research work.
  • All te space for you to contribute shaping the care of tomorrow.
  • Working on large-scale and research project, with motivated colleagues from all over the world.
  • We offer a contract for a year (12 months) with the intention to be extended for another 36 months.
  • Additional benefits include an 8.3% end-of-year bonus and 8.0% holiday pay.
  • The base salary does not include holiday pay (8%) and a year-end bonus (8.3%). 
  • In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
  • Pension is accrued at Be Frank. 

Additional comments

What to expect

+ A job in our beautiful capital
+ Working for the most preferred employer in healthcare (intermediair 2021)
+ All colleagues have the same goal: contributing to tomorrow's care
+ We care not only for our patients, but also for you
+ Cooperation is characterised by mutual trust and interest in one another

- We are constantly innovating, so you must be able to deal with change
- Parking is limited at location VUmc, but by public transport you can get to the door
- A full agenda, because our staff association organises many fun activities

You can find more information on the consortium on the DARTBAC website. Please feel free to contact Dr. Payal Balraadjsing via p.balraadjsing@amsterdamumc.nl (postdoc) or Dr. Sebastian (Bas) A.J. Zaat (PI) via s.a.zaat@amsterdamumc.nl for more information.
For more information about the application procedure please contact Tanja Hart, Recruitment adviser, via 06-21603178 or t.hart@amsterdamumc.nl.
Please apply by providing (in English) your CV and motivation letter, and if available recommendation letter(s) and other relevant certificates. The selection procedure will consist of initial preselection by an internal AMC selection committee based on your motivation letter and resumé followed by an interview. The preferred starting date for this position is early 2022.

Web site for additional job details

Offer Requirements

Specific Requirements

About you
We are looking for an enthusiastic and creative PhD candidate with a master’s degree or equivalent in (micro)biology, biomedical sciences, (veterinary) medicine or a related field, with a keen interest in infectious diseases and willing to conduct animal experiments. Experience in microbiology, immunology and/or working with animal models (mice or rat) is considered a strong advantage. Being certified to conduct animal experiments in the EU (Art. 9/FELASA license or equivalent) is highly recommended. You are able to work in an international team and to work independently in analysing, interpreting and reporting data. Good communication skills and proficiency in English, and the ability to work in a highly multidisciplinary environment are essential.

Work location(s)
1 position(s) available at
Amsterdam UMC
1105 AZ
Meibergdreef 9

EURAXESS offer ID: 703240
Posting organisation offer ID: 305897


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