24/09/2021

PhD student | ‘Finding lost connections in Alzheimer’s disease’

This job offer has expired


  • ORGANISATION/COMPANY
    VU university medical center (VUmc)
  • RESEARCH FIELD
    Medical sciences
    Physics
    Technology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    17/10/2021 23:59 - Europe/Brussels
  • LOCATION
    Netherlands › Amsterdam
  • TYPE OF CONTRACT
    Temporary
  • HOURS PER WEEK
    36.0

OFFER DESCRIPTION

The most common cause of dementia is Alzheimer’s disease (AD). AD starts with amyloid beta aggregation in the brain, 20 years before the onset of dementia. This long time period provides opportunities to prevent dementia. It is known that loss of brain connectivity is central to the clinical manifestation of AD. Moreover, dysconnectivity also plays a role in non-AD dementia syndromes. In this project you study the genetic factors that are associated with strong or with vulnerable brain connections as measured on MRI scans in the Amsterdam Dementia Cohort as a discovery cohort, and replicate findings in independent other large cohorts. You investigate which combined genetic and brain connectivity patterns are specific or generic across different dementia disorders, and whether genetic factors related to brain connectivity can be found that explain differences between individuals in disease progression. This research is part of a VIDI funded project and includes collaborations with the Neuroscience Campus Amsterdam, as well as with large scale European consortia.

About the project
The most common cause of dementia is Alzheimer’s disease (AD). AD starts with amyloid beta aggregation in the brain, 20 years before the onset of dementia. This long time period provides opportunities to prevent dementia. It is known that loss of brain connectivity is central to the clinical manifestation of AD, and also in non-AD dementia causing diseases. Moreover, strong brain connectivity is associated with resilience to dementia. In this project you will study and potentially discover the genetic factors that are associated with strong or with vulnerable brain connections as measured on MRI scans in the Amsterdam Dementia Cohort as a discovery cohort, and replicate findings in independent other large cohorts. You investigate which combined genetic and brain connectivity patterns are specific or generic across different dementia disorders, and whether genetic factors related to brain connectivity can be found that explain differences between individuals in disease progression. This research is part of a VIDI funded project and includes collaborations with the Neuroscience Campus Amsterdam, as well as with large scale European consortia. 

More Information

Benefits

We offer a four year PhD contract (starting for 12 months, to be extended for another 36 months upon evaluation).
The salary scale starts according to PhD guidelines at € 2.495,- in the first year, growing to € 3.196,-  in the last year (based on a 36 hour contract).

In addition, we offer:

  • Additional benefits include an 8.3% end-of-year bonus and 8.0% holiday pay.
  • The opportunity to follow further training and development.
  • Pension is accrued at the ABP. VUmc contributes a large part of the premium (70%).
  • In addition to excellent accessibility by public transport, we reimburse 75% of your OV travel costs (commuting costs).

For more information about our employment conditions, please visit our website.

Additional comments

Wat kun je verwachten?

+ Een baan in onze prachtige hoofdstad
+ Werken bij de meest favoriete werkgever in de zorg (intermediair 2021)
+ Alle collega's hebben hetzelfde doel: bijdragen aan de zorg voor morgen
+ Wij zorgen niet alleen voor onze patiënten, maar ook voor jou
+ Samenwerking kenmerkt zich door onderling vertrouwen en interesse voor elkaar
+ Er is ruimte voor ontplooiing, verdieping en verbreding van je kennis

- Amsterdam UMC innoveert continu, je moet dus om kunnen gaan met verandering
- Op locatie VUmc kun je beperkt parkeren, maar met het OV stap je voor de deur uit
- Op locatie AMC is het vaak iets langer lopen naar je werkplek, maar daardoor springt je stappenteller sneller op groen
- Een volle agenda, want onze personeelsvereniging organiseert veel leuke activiteiten

We look forward to receive your motivation letter and CV!
The first round of interviews is scheduled for the week of 18 october. We ask you to take this into account. 
Preferred start date for this position is 1 December 2021.
For more information about this position, you can contact Betty Tijms, Sr. Researcher via b.tijms@amsterdamumc.nl.
For more information about the application procedure please contact Tanja Hart, Recruitment Adviser, via T: 06-21603178 or E: t.hart@amsterdamumc.nl

A reference check, screening and hiring test may be part of the procedure. Read here whether this also applies to you. If you join us, we ask for a VOG (Certificate of Good Conduct). Foreign citizens need to provide comparable police clearing certificates.
Internal takes precedence over external in case of equal suitability.
Acquisition in response to this vacancy is not appreciated.

Web site for additional job details

Offer Requirements

Specific Requirements

  • MSc in bioinformatics, systems biology, neuroscience, biomedical science, or related fields.
  • Demonstrable experience with analysis of large complex data sets, preferably with experience in genomic fields or MRI processing;
  • Experience with statistical software R, and experience with PLINK is preferred;
  • Experience with Python is preferred;
  • Knowledge and understanding of ontological databases such as KEGG, and GO;
  • Understanding of bioinformatical tools (e.g., IPA);
  • Organisational, communicative and cooperative skills, as you will collaborate with scientists from multiple scientific disciplines.

Work location(s)
1 position(s) available at
VU University Medical Center (VUmc)
Netherlands
Amsterdam
1081 HV
De Boelelaan 1117

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EURAXESS offer ID: 689097
Posting organisation offer ID: 304698

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