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EURAXESS

1 PhD position in the MSCA Doctoral Network “BREAKthrough”

30 Jan 2023

Job Information

Organisation/Company
de Duve Institute
Department
BCHM
Research Field
Medical sciences » Other
Biological sciences » Biological engineering
Researcher Profile
First Stage Researcher (R1)
Country
Belgium
Application Deadline
Type of Contract
Temporary
Job Status
Full-time
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
HE / MSCA
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

DC03: Identification of new OM destabilizers by targeting RcsF-Bam and the crosslinking of Lpp to the PG

Project description

Antimicrobial resistance, which is caused by multi-drug-resistant bacterial pathogens is a global health emergency. Gram-negative bacteria notably hinder effective treatment because of their impermeable outer membrane (OM).

This project aims at investigating the interaction between lipoproteins and the beta-Barrel Assembly Machinery (BAM) using various in vivo and in vitro approaches. These approaches include site-specific photocrosslinking, pulldowns, protein purification and micro fluidics.

One objective of the BREAKthrough European Training Network (ETN) is to destabilize the OM to make Gram-negative bacteria sensitive to new antibiotics. In this context, the potential of poorly characterized peptidoglycan transpeptidases as drug targets will be explored.

Requirements

Research Field
Biological sciences » Other
Education Level
Master Degree or equivalent
Skills/Qualifications
Candidate profile : Master’s degree in Microbiology, Molecular Biology, Biochemistry, or a related discipline
Specific Requirements

Complete applications are written in English and include:

  • A CV
  • A letter of motivation
  • Contact details of two referees

 

To be eligible for any doctoral candidate position in the BREAKthrough project, applicants must fulfil the following criteria.

  • You have not already completed (or successfully defended) a PhD degree.
  • You have not resided or carried out your main activity (work, studies, etc.) in the country of the recruiting institution for more than 12 months in the 36 months immediately before your starting date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status are not taken into account.
  • You are proficient in English (specific requirements may apply depending on the position).

 

Languages
ENGLISH
Level
Good

Additional Information

Benefits

The successful candidate will work in a vibrant, international environment with state-of-the-art equipment and a highly supportive community. The lab, an independent group of about 15 people, is an internationally recognized team in the field of the bacterial envelope biogenesis. The lab is part of the de Duve Institute, founded by the Nobel Prize winner Christian de Duve (http://www.deduveinstitute.be/bacteria). The de Duve Institute is a multidisciplinary biomedical research institute with more than 250 scientists from all over the world.

The fellow will benefit from the ITN consortium’s activities (networking, soft skills trainings). He/She will also have the opportunity to participate to international meetings.

The successful candidate will benefit from free public transportation in Brussels and from the Belgian Social Security.

Eligibility criteria

To be eligible for any doctoral candidate position in the BREAKthrough project, applicants must fulfil the following criteria.

  • You have not already completed (or successfully defended) a PhD degree.
  • You have not resided or carried out your main activity (work, studies, etc.) in the country of the recruiting institution for more than 12 months in the 36 months immediately before your starting date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status are not taken into account.
  • You are proficient in English (specific requirements may apply depending on the position).
Selection process

Selection of few candidates will be made on the basis of a complete application (CV + letter of motivation).

Selected candidates will have at least one online interview.

Website for additional job details

Work Location(s)

Number of offers available
1
Company/Institute
de Duve Institute - UCLouvain
Country
Belgium
City
Brussels
Postal Code
1200
Street
Avenue Hippocrate 75
Geofield

Where to apply

E-mail
jfcollet@uclouvain.be

Contact

City
Brussels
Street
Avenue Hippocrate 75
Postal Code
1200
E-Mail
jfcollet@uclouvain.be
pauline.leverrier@uclouvain.be