Job Information
- Organisation/Company
- Amsterdam UMC, Cancer Center Amsterdam
- Department
- Immunotherapy Laboratory and Tumor Immunomonitoring Unit
- Research Field
- Pharmacological sciences » Clinical pharmacologyMedical sciences » MedicineBiological sciences » Biological engineeringBiological sciences » BiologyBiological sciences » Other
- Researcher Profile
- First Stage Researcher (R1)
- Country
- Netherlands
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- H2020
- Marie Curie Grant Agreement Number
- 955575
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
Who we are
T-OP – Training Network for Optimizing Adoptive T cell Therapy of Cancer is an Initial Training Network funded by the European Union. It started on March 1st 2021 and has a duration of four years. The network comprises 17 partners, from academy, industry and public authority, located in seven different countries.
Scientific scope
T-OP aims at improving the efficacy and production of cell therapies. It will enable future experts to develop new therapeutic solutions providing them with a program of excellence.
Over the last years, immunotherapy – using a patient’s own immune system to fight tumours – has emerged as an important complement to standard treatments. The clinical implementation of immunotherapeutics has established T cells as efficient anti-cancer weapons if targeted by specific drugs. Their therapeutic utilization has recently come to a breakthrough: adoptive T cell therapy (ACT), collecting and transforming the patient’s own T cells to treat cancer.
The generation of such ACT products is a complex but ill-defined process with limited harmonization across production and clinical studies, even for the same indication. Cytokines are a key element of these products as they are responsible for the growth and differentiation of T-cells.
There is however a limited understanding as to which cytokines might lead to the best outcome on any of these steps. T-OP targets a pioneering research question: how do cytokines influence the therapeutic outcome of ACT products? T-OP brings together interdisciplinary and cross-sectorial teams spanning large and small-sized companies as well as experts in different aspects of cell therapy, immunology, protein engineering and bioinformatics.
We offer: Cutting edge research project and training with leading experts in the field of cell therapy; employment contract in full time with the benefits of the EU Marie Skłodowska-Curie program, to be started as soon as possible and ended on February 28th, 2025.
Open position:
Project 3 (ESR3): Cytokine requirements for efficient expansion of peripheral blood and tumour-derived mucosal associated invariant T (MAIT) cells for ACT of cancer. In the Netherlands, Amsterdam, at Amsterdam UMC, Cancer Center Amsterdam, supervised by Tanja D. de Gruijl and Hans J. van der Vliet for the duration of two years.
Requirements
- Research Field
- Pharmacological sciences » Clinical pharmacology
- Education Level
- Master Degree or equivalent
- Research Field
- Medical sciences » Medicine
- Education Level
- Master Degree or equivalent
- Research Field
- Biological sciences » Biological engineering
- Education Level
- Master Degree or equivalent
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
- Research Field
- Biological sciences » Other
- Education Level
- Master Degree or equivalent
We seek: Excellent scientist with a Master’s degree or equivalent in natural sciences or related disciplines (such as medicine or pharmacy); practical skills in modern laboratory work, preferentially combined with experience in animal experiments.
Your profile: You must be within your first four years of research experience after completion of your Master's degree or equivalent; you cannot hold a doctoral degree (except medical doctor) at the time of recruitment; you cannot have spent more than 12 months within the past 36 months in the country where the position you are applying for is located (mobility rule); you must be proficient in the English language both written and spoken (proof required).
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Medical sciences » MedicinePharmacological sciences » Clinical pharmacologyBiological sciences » Biological engineeringBiological sciences » BiologyBiological sciences » Other
- Years of Research Experience
- 1 - 4
Additional Information
Cutting edge research project and training with leading experts in the field of cell therapy; employment contract in full time with the benefits of the EU Marie Skłodowska-Curie program, to be started as soon as possible and ended on February 28th, 2025.
You will benefit from the experience of a running and successful network whose value are based on excellence, collaboration, curiosity and kindness
You must be within your first four years of research experience after completion of your Master's degree or equivalent; you cannot hold a doctoral degree (except medical doctor) at the time of recruitment; you cannot have spent more than 12 months within the past 36 months in the country where the position you are applying for is located (mobility rule); you must be proficient in the English language both written and spoken (proof required).
Excellence of qualification, experience and skills
1. First stage of selection:
a. Eligibility check carried out by T-OP management team:
- The candidates are in the first four years* (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree (except medical doctor).
- The candidates must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to his/her recruitment.
*is measured from the date when a researcher obtained the degree which would formally entitle him or her to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher is recruited, irrespective of whether or not a doctorate is or was ever envisaged.
Solely the candidates that comply with the criteria of eligibility will be assessed.
b. Assessment of the application forms by the Project Leader and her team:
- Quality of education (degrees and transcript)
- Education matching to the skills required
- Quality of research experience
- Research experience matching to required skills
- Quality of language skills
- Quality of references
- General evaluation of profile based on motivations and personal skills
- Experience of Mobility (geographical, sectoral, virtual)
2. Second stage of selection:
- Quality of the presentation
- General evaluation of profile depending on motivations and personal skills
- References
- Website for additional job details
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Amsterdam UMC, Cancer Center Amsterdam
- Country
- Netherlands
- City
- Amsterdam
- Postal Code
- 1081 HV Amsterdam Post
- Street
- VUmc, CCA 2.44 DE BOELELAAN 1117
- Geofield
Where to apply
- Website
Contact
- State/Province
- Bavaria
- City
- Amsterdam
- Website
- Street
- VUmc, CCA 2.44 DE BOELELAAN 1117
- Postal Code
- 1081 HV Amsterdam Post
- simone.gautier@med.uni-muenchen.de