28/05/2021

PhD position “Development of novel synthetic methodologies on glycals applied to the development of antiviral agents”

This job offer has expired


  • ORGANISATION/COMPANY
    Université de Namur
  • RESEARCH FIELD
    ChemistryBiochemistry
    ChemistryOrganic chemistry
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    15/07/2021 23:00 - Europe/Brussels
  • LOCATION
    Belgium › Namur
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    38
  • OFFER STARTING DATE
    01/09/2021

OFFER DESCRIPTION

Context – This PhD thesis will be performed in close collaboration with the laboratories of Prof. Berionni and Prof. Robiette (2 other PhD students recruited in parallel). The biological applications will be realized either in the Biology Department of UNamur or in the Rega Institute (KULeuven, internationally renowned in virology and for the development of antiviral drugs, https://rega.kuleuven.be/).

Project – The CBO laboratory has a long experience in the chemistry of exo-glycals (enol ethers derived from carbohydrates) either for the design of enzyme inhibitors (Chem. Eur. J. 2016, 22, 15913) or for the development of novel synthetic methodologies (for instance the photoredox trifluoromethylation of exo-glycals Org. Lett. 2018, 20, 6769). The first part of the PhD thesis will be dedicated to the development of new reactions using exo-glycals, in particular using organoboron chemistry (expertise of the Berionni lab). The reaction mechanisms will be studied in close collaboration with the Robiette laboratory. The second part of the PhD thesis will be dedicated to apply the new reactions to the synthesis of viral enzymes’ inhibitors (collaboration with the Rega Institute, KULeuven) or as glycomimetics.

PhD duration: 4 years (starting in sept-october 2021)

Funding : PhD fellowship ARC (Action de Recherche Concertée)

More Information

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

A Master degree in synthetic organic chemistry is required (graduation not earlier than 2019).

Work location(s)
1 position(s) available at
Université de Namur
Belgium
Namur
5000
Rue de Bruxelles, 61

EURAXESS offer ID: 645228

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