POSTDOC

The International Institute of Molecular Mechanisms and Machines (IMol) Polish Academy of Sciences, was constituted in December 2020, in partnership with University Medical Center Göttingen, Germany and University of Warsaw, Poland.

IMol has been established to conduct scientific research and provide training in the fields of biological, chemical, medical, biotechnological, bioinformatics, biophysical, pharmacological, and similar sciences, in the international environment conducive to collaborative efforts, research and development interactions with biotechnological industry, and wide dissemination of our results.

Currently IMol is seeking for highly motivated candidates for a position of: POSTDOC

A few words about the research group:

Laboratory of Mitochondrial Biogenesis led by Prof. Agnieszka Chacińska is a research group with an excellent publication record in molecular cell biology. We are interested in fundamental cellular mechanisms in physiology as well as in pathology and ageing. Our research is focused on mechanisms of protein import to mitochondria and on the cellular response to dysfunction of these mechanisms. We use diverse model systems such as human cells, yeast, fish Danio rerio and worm Caenorhabditis elegans.

We offer:

- Work in an active team in an excellent scientific environment

- Access to state-of-the-art equipment and facilities

- Participation in courses and conferences

- Comprehensive training in biochemistry, cell and molecular biology techniques

- Type of contract: full-time, fixed-time contract of employment, ca. 6.500 PLN net/month

Project leader: Prof. Agnieszka Chacińska, PhD

Project title: “Effects of proteasome inhibition on mitochondrial homeostasis.”

Project description: Great majority of proteins that build mitochondria are encoded in the nuclear genome, synthesized by cytosolic ribosomes in precursor forms and actively transported to their target location in mitochondria. Recent studies, with the major contribution of our group, showed that the proteasome plays an important role in the quality control of proteins transported to mitochondria and that proteasome inhibitors have therapeutic potential against some mitochondrial diseases. The aim of this project is to explore the influence of proteasomal inhibition on fully functional and defective mitochondria.

Description of your tasks:

- Performing experiments using biochemical, cell and molecular biology techniques (independently and in collaboration with other team members)

- Designing experiments and analysing data

- Writing manuscripts

- Participation in the supervision of MSc and PhD students

- Participation in the preparation of grant applications

- Active participation in lab meetings, scientific seminars and conferences

Requirements:

- Doctoral degree in molecular biology, genetics or biochemistry;

- Strong publication record and experimental training;

- Ability to work both independently and as a part of a team;

- Ability to communicate fluently in English (written and spoken);

- Strong motivation to work and pursue scientific questions, creativity and analytical thinking;

- Research experience in another area of molecular biology will be advantageous

Please prepare the following documents (you will be asked to submit the documents merged into one pdf file while filling out the application form linked below):

- Motivation letter;

- CV;

- A list of publications and conferences attended;

- Contact details of previous supervisors for reference (please do not attach generic reference letters but contact details instead)

If you think you are the person who we are looking for, please apply by filling in this form: https://forms.gle/Exoy7iw4U8cYLL9C6