09/05/2021

Fully funded PhD position in FWF-PhD programme HOROS

This job offer has expired


  • ORGANISATION/COMPANY
    Medical University of Innsbruck
  • RESEARCH FIELD
    Biological sciencesBiology
    Biological sciencesOther
    Medical sciencesOther
    Pharmacological sciencesOther
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    31/08/2021 23:00 - Europe/Brussels
  • LOCATION
    Austria › Innsbruck
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/11/2021
  • REFERENCE NUMBER
    HOROS-W1253
  • IS THE JOB RELATED TO STAFF POSITION WITHIN A RESEARCH INFRASTRUCTURE?
    Yes

OFFER DESCRIPTION

HOROS - Host Response in Opportunistic Infections, a FWF-funded doctoral collage has one fully funded PhD position on the broader topic of Microbiology and Immunology on offer:

‍‍

Project: Met-Iron-Inf

Under supervision of Prof. Günter WeissProf. Cornelia Lass-Flörl and Prof. Doris Wilflingseder you will work on the topic of "Metabolic iron changes during SARS-CoV-2 infection in vitro".

Excessive inflammation triggered by a hitherto undescribed mechanism is a hallmark of severe SARS-CoV-2 infections and is associated with enhanced pathogenicity and mortality. 88% of COVID-19 patients illustrate metabolic iron changes during infection with SARS-CoV-2.

Our groups have long-standing expertise in studying in detail infectious diseases and host-pathogen interactions taking into account the complement system. Further, the Wilflingseder lab has established a primary, human pseudostratified 3D respiratory epithelial/immune model over the last years. This model is very versatile, since innate and adaptive components of the immune system can be easily added. During the last year, the Weiss and Wilflingseder labs successfully expanded novel variants of SARS-CoV-2 patient isolates and worked on various projects resulting in high impact publications on SARS-CoV-2 interactions and therapeutic interventions (Posch et al., 2021a, b, c; Lafon et al., in revision).

The successful PhD student should have a background in advanced cell biology and/or immunology to perform exciting research questions on deregulated host iron homeostasis, involvement of complement in SARS-CoV-2-mediated type I IFN response of infected tissues and on the connection of iron homeostasis, host metabolism, innate antiviral immune responses and complement functionality. State-of-the-art methods will be used (multi-parameter flow cytometry, high content screening, multiplex PCR). To tackle this complex task with an important translational impact, we are looking for a highly motivated PhD student. We offer a broad and stimulating environment of various disciplines since our institutes host several labs such as category 3 laboratory for virus work, molecular immunology lab and screening facilities.

Please see here the full project description.

 

 

Please see here the full project description.

For detailed descriptions of the projects go to:

http://www.horos.at/content/home/application/

Why Horos?

• Individual supervision and monitoring (students have their individual thesis steering

committee)

• A highly structured HOROS-specific educational programme

• Great scientific network, also with international laboratories

• Retreats and social activities

• Guaranteed salary as suggested by the Austrian Science Fund for the proposed 3-

years, health insurance and social benefits (https://www.fwf.ac.at/en/research-funding/personnel-costs)

• State-of-the art facilities and resources

 

 

Application

To submit your application, please go to the HOROS application page (http://www.horos.at/content/home/application/).

Documents needed:

 • CV

• filled application form

• university entry permission

• Master/MD/diploma degree

• recommendation letter

• abstract of diploma/master/MD thesis

 

We can only accept complete applications. Incomplete applications will not be

considered!

PhD students are selected on the basis of their application materials and the selected

candidates will be invited to a personal interview at Medical University Innsbruck.

 

 

Selection process

• Verification that the application is complete and that the applicant fulfils all requirements

• Evaluation by HOROS faculty members and ranking of candidates based on their qualifications, research experience, and future plans

• Invitation of preselected candidates for a hearing and personal job interview in Innsbruck/ online interviews on 29th September 2021(depending on the pandemic situation in Sep; justifiable expenses for travel and accommodation will be reimbursed)

• Final selection of stipendiates

• Start of project 01st November 2021

 

Application deadline: 31. August 2021 23.59h CET

Interviews: 29. September 2021

Start of work: 01. November 2021

More Information

Offer Requirements

Skills/Qualifications

The entry requirement is a full study completing degree (Master, Magister, Diploma, MD) in medicinenatural sciences or related disciplines. Medical or Science students have to show academic excellence, scientific potential, flexibility, motivation and suitability for the research project.

Work location(s)
4 position(s) available at
Medical University of Innsbruck
Austria
Tyrol
Innsbruck
6020
Schöpfstraße 41

EURAXESS offer ID: 638232

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