04/05/2021
Marie Skłodowska-Curie Actions

Ph.D. in Neuroscience

This job offer has closed


  • ORGANISATION/COMPANY
    Institut de Neurosciences des Systèmes (INS)
  • RESEARCH FIELD
    NeurosciencesNeurobiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    01/10/2021 12:00 - Europe/Brussels
  • LOCATION
    France › Marseille
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    39
  • OFFER STARTING DATE
    01/09/2021
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • REFERENCE NUMBER
    ASTROTECH
  • MARIE CURIE GRANT AGREEMENT NUMBER
    956325

OFFER DESCRIPTION

Project: Disruption of K+ clearance and metabolic processes in astrocytes at seizure onset.

The researcher will be part of ASTROTECH, an European Training Network that includes 15 Ph.D. students in different labs all over Europe. ASTROTECH will implement “training-through-research” by the development and application of innovative technologies & methodologies, targeting the monitoring, the study, and the manipulation of the function of glial cells called astrocytes and their role and interaction with neurons at multiple scales: from intracellular and subcellular synaptic level, to cellular and neural circuits to behaviour, in both time and space.

This particular project is focused on epilepsy and has the following objectives: A) To measure astrocytic function in experimental epilepsy, combining Ca2+ imaging, electrophysiological, metabolic (glucose and lactate) and ionic (K+) recordings, and establish whether changes occur before seizure onset (biomarker identification) and are causally related to seizure genesis (mechanism). B) Validation of biolectronic devices (state-of-the-art technologies developed by the consortium) for assessing astrocyte function in vivo. C) Testing theoretical predictions obtained from whole brain simulations (The Virtual Mouse brain) performed by another ASTROTECH Ph.D. student working in the same institute.

Expected Results: Validation of biolectronic devices for in vivo recordings. Identification of a predictive biomarker of seizures. Identification of the mechanism of seizure onset for a type of focal seizures.

Skills acquired: Fundamental knowledge on neurobiology, glial biology and physiology; ethical aspects; animal models of epilepsy; in vivo electrophysiology and imaging; telemetry; functional morphology; patch-clamp; device fabrication and characterization; signal processing; comprehensive training on transferable skills.

More Information

Benefits

The fellowship comes with a competitive salary (beyond national averages) within the prestigious Marie Skłodowska-Curie Actions scheme and with grant money for participating to training, conferences. 

In addition to the training providing within the "ASTROTECH" international program, the candidate will also profit ot the local "Neuroschool" graduate program (https://neuro-marseille.org/) offering high-level training (in English language) in integrative neuroscience, research management and soft skills, within one of the largest neuroscience communities in France. Aix-Marseille University is one of few excellence-labelled universities (IDEX) in France, making of interdisciplinary research one of its main axes. Marseille is a vibrant city with wonderful natural surroundings and high-speed train and flight connections to many large cities in Europe.

The candidate will have the opportunity to visit and work in the other labs and private companies of ASTROTECH.

Eligibility criteria

By EU rules, candidates must not have resided or carried out their main activity (work, studies, etc.) in France for more than 12 months in the 3 years immediately before the recruitment date.

Selection process

The top-ranked candidates are then going to be interviewed orally and finally selected through a competitive, equal-opportunities procedure.

Applying candidates are strongly invited to make a parallel inquiry by writing to us directly, including a motivation letter, a CV, the name of two references and any other information that you may wish to share.

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Neurosciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

Previous experience is expected in either

in vivo/in vitro electrophysiology in the brain

Ca imaging

metabolic imaging/recording

Specific Requirements

Candidates must not have resided or carried out their main activity (work, studies, etc.) in France for more than 12 months in the 3 years immediately before the recruitment date.

Proficiency in Matlab or Python is a plus.
 

Map Information

Job Work Location Personal Assistance locations
Work location(s)
2 position(s) available at
Inserm U1106 Institut de Neuroscience des Systèmes
France
Marseille
13385
27 Bd jean Moulin

EURAXESS offer ID: 636288

Disclaimer:

The responsibility for the jobs published on this website, including the job description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.

 

Please contact support@euraxess.org if you wish to download all jobs in XML.