29/04/2021
European Research Council

PhD Candidate / PostDoc in Hyperpolarized Magnetic Resonance

This job offer has expired


  • ORGANISATION/COMPANY
    Karlsruhe Institute of Technology
  • RESEARCH FIELD
    ChemistryPhysical chemistry
    EngineeringElectrical engineering
    PhysicsApplied physics
    PhysicsQuantum mechanics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    31/10/2021 23:00 - Europe/Brussels
  • LOCATION
    Germany › Eggenstein-Leopoldshafen
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    39.5
  • OFFER STARTING DATE
    01/12/2021
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / ERC
  • REFERENCE NUMBER
    951459

OFFER DESCRIPTION

ERC Synergy Grant Staff Opportunity

Our recently funded ERC Synergy Grant HiSCORE seeks to advance hyperpolarisation, miniaturisation, parallelisation and spin dynamics, and combine these research themes for highly informative drug discovery by nuclear magnetic resonance. We believe that, eventually, magnetic resonance can provide an in-depth biophysical characterisation of drug candidates in a much shorter time than today, and become a very effective platform for rapid drug discovery.

This highly interdisciplinary project is run by four laboratories (Geoffrey Bodenhausen, Arno Kentgens, Jan G. Korvink, and Benno Meier) in three institutions (ENS Paris, Radboud University Nijmegen, and Karlsruhe Institute of Technology). Our partners Alvar Gossert (ETH Zürich) and Claudio Dalvit (Trento) complete our team with strong expertise in magnetic resonance (MR) based drug discovery.

We now invite applications from prospective PhD candidates, postdocs and research engineers to join this ambitious research programme. Several positions are available, and we expect frequent and in-depth exchanges between the participating labs. PhD positions may be supervised jointly, and enable one to obtain experience in the participating institutions. The focus of the individual labs, along with open positions, is detailed below.

The IBG4 lab at KIT headed by Meier will develop bullet-dynamic nuclear polarization (bullet-DNP), and scale the supply of hyperpolarised drug candidates. This involves a substantial parallelisation of the polarisation step, where we target to hyperpolarise 100 samples simultaneously. We will also study DNP mechanisms to reduce the polarisation time per sample, and explore DNP mechanisms such as the solid effect that require substantial microwave power. Further research branches are the liquefaction of hyperpolarized solids, and the time-efficient characterisation of drug binding.

We are equipped with two 50 mm bore, 9.4 T cryogenic polarizers, that can be combined with AWG-driven microwave sources operating at 188 and 263 GHz. A 2 Tesla fast-field cycling system is available for relaxometry. A Klystron based DNP system operating at 95 GHz is planned. For liquid-state NMR we are equipped with Bruker 400 MHz NB and WB magnets with multi-channel consoles. Additionally we run a state-of-the-art CNC workshop (Haas SMM2, ST10) and a Bezerra Mitika Top.

Our lab invites applications of enthusiastic post-doctoral researchers with a degree in Physics, Chemistry or a related area, and PhD candidates. Research will focus on:

  • Development of highly parallel and fast hyperpolarization with DNP
  • Control of relaxation and thermal mixing during the transfer of hyperpolarized materials.
  • Development of rapid distribution and detection of hyperpolarized material across many parallel detectors.
  • High throughput MR-based detection and characterisation of ligand binding

The post-doc positions are available for 2 years with a possibility to extend. The PhD positions are available for 3 years at 75% FTE.

 

More Information

Selection process

Please address your application to Dr Benno Meier. Your application should include the following attachments:

  • Letter of motivation
  • CV

 

Additional comments

For more information about this vacancy, please contact:

Dr. B. Meier

Email: benno.meier@kit.edu

Offer Requirements

Skills/Qualifications

For PhD candidates a Master's Degree in Physics, Chemistry or a related area is required with marks in the upper 10% of the class.

For postdocs, a PhD in Physics/Chemistry or a related area is required, with previous experience in magnetic resonance (experimental and/or theoretical).

 

Specific Requirements

For PhD candidates excellent communication skills, team spirit, and skill in data analysis are required. Knowledge of a programming language (Python, Matlab or similar) is beneficial. Previous experience in magnetic resonance is highly desirable.

For postdocs, additionally in-depth experience in one or several of the following areas is required: dynamic nuclear polarization, RF and microwave engineering / hardware development, advanced liquid-state NMR spectroscopy, microfluidics.

 

Work location(s)
3 position(s) available at
Institute of Biological Interfaces 4
Germany
Eggenstein-Leopoldshafen
76344
Herrmann-von-Helmholtz-PLatz 1

EURAXESS offer ID: 634323

Disclaimer:

The responsibility for the jobs published on this website, including the job description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.

 

Please contact support@euraxess.org if you wish to download all jobs in XML.