RESEARCH FIELDEngineering › Biomedical engineeringTechnology › Nanotechnology
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE31/05/2021 23:59 - Europe/Brussels
LOCATIONBelgium › Leuven
TYPE OF CONTRACTTo be defined
HOURS PER WEEK38
For the Biosensors group (www.biosensors.be) of the Department of Biosystems at KU Leuven we are looking for a PhDstudent to work in the field of bionanotechnology and more specifically on the developmentof novel DNA nanotechnology-based strategies for continuous fiber opticbiosensing.Healthcare is in demand oftechnologies for continuous sensing in order to guard the state of patients,based on real-time, precise, and reliable data. Sensors for monitoring patients’heart rate, muscle action, electrocardiography, temperature, blood pressure,and respiratory rate are well known. However, these sensors all rely onphysical effects rather than on the underlying biomolecular processes. Theability to continuously observe biomolecular parameters such as peptides,proteins, small molecules, and nucleic acids has the potential to revolutionisehealth care for monitoring of disease status and treatment effect. Present-daymethods and sensors for continuous monitoring are either non-specific, notsensitive enough or too slow. Therefore, novel generic biosensor technologiesare needed for the continuous monitoring of biomarkers at nanomolar topicomolar concentrations, in order to observe disease status and treatmenteffect. This requires an interdisciplinary (molecular engineering, sensingtechnology, clinical applications) and intersectoral approach (academic,hospital, industry).
The CONSENSE project,funded under the Marie Sklodowska-Curie Action H2020-MSCA-ITN-2020, responds to this need by involving 9 differentbeneficiaries from 8 European countries and 7 partner organisations to providean excellent interdisciplinary,intersectoral and international research and training platform in thecontext of continuous biosensing. Through this project, a new generation of 15 innovative,entrepreneurial and creative early-stage researchers (ESRs) will be trainedwith knowledge/skills to become the futureacademic or industrial leaders in this field.
For KU Leuven,as one of the partners in this EU project, we are looking for a PhD student whowill be working on the development of innovative optical biosensors based onDNA nanotechnology for continuous monitoring in biofluids. More specifically, thePhD candidate will work on a molecular nanoswitch-based fiber-optic (FO)-SPRbioassays with a focus on: 1) control over the nanoarchitecture of thebioreceptors through 2D and 3D DNA origami structures, 2) integratedaptamer-based molecular nanoswitch concepts and 3) demonstrating proof-of-conceptwith good stability, specificity, sensitivity and repeatability for continuousmonitoring in biological fluids (e.g., serum and blood).
For more information please contact Prof. dr. ir. Jeroen Lammertyn, tel.: +32 16 32 14 59, mail: email@example.com or Mrs. Dragana Spasic, tel.: +32 16 37 71 18, mail: firstname.lastname@example.org.
You can apply for this job no later than 31/05/2021 via the online application tool
Web site for additional job details
EURAXESS offer ID: 633671
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