28/04/2021

Continuous biosensing of biofluids with DNA origami-based fiber optic technology


  • ORGANISATION/COMPANY
    KU Leuven
  • RESEARCH FIELD
    EngineeringBiomedical engineering
    TechnologyNanotechnology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    31/05/2021 23:59 - Europe/Brussels
  • LOCATION
    Belgium › Leuven
  • TYPE OF CONTRACT
    To be defined
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    38
  • REFERENCE NUMBER
    BAP-2021-320

OFFER DESCRIPTION

For the Biosensors group (www.biosensors.be) of the Department of Biosystems at KU Leuven we are looking for a PhDstudent to work in the field of bionanotechnology and more specifically on the developmentof novel DNA nanotechnology-based strategies for continuous fiber opticbiosensing.Healthcare is in demand oftechnologies for continuous sensing in order to guard the state of patients,based on real-time, precise, and reliable data. Sensors for monitoring patients’heart rate, muscle action, electrocardiography, temperature, blood pressure,and respiratory rate are well known. However, these sensors all rely onphysical effects rather than on the underlying biomolecular processes. Theability to continuously observe biomolecular parameters such as peptides,proteins, small molecules, and nucleic acids has the potential to revolutionisehealth care for monitoring of disease status and treatment effect. Present-daymethods and sensors for continuous monitoring are either non-specific, notsensitive enough or too slow. Therefore, novel generic biosensor technologiesare needed for the continuous monitoring of biomarkers at nanomolar topicomolar concentrations, in order to observe disease status and treatmenteffect. This requires an interdisciplinary (molecular engineering, sensingtechnology, clinical applications) and intersectoral approach (academic,hospital, industry). 

The CONSENSE project,funded under the Marie Sklodowska-Curie Action H2020-MSCA-ITN-2020,  responds to this need by involving 9 differentbeneficiaries from 8 European countries and 7 partner organisations to providean excellent interdisciplinary,intersectoral and international research and training platform in thecontext of continuous biosensing. Through this project, a new generation of 15 innovative,entrepreneurial and creative early-stage researchers (ESRs) will be trainedwith knowledge/skills to become the futureacademic or industrial leaders in this field. 

For KU Leuven,as one of the partners in this EU project, we are looking for a PhD student whowill be working on the development of innovative optical biosensors based onDNA nanotechnology for continuous monitoring in biofluids. More specifically, thePhD candidate will work on a molecular nanoswitch-based fiber-optic (FO)-SPRbioassays with a focus on: 1) control over the nanoarchitecture of thebioreceptors through 2D and 3D DNA origami structures, 2) integratedaptamer-based molecular nanoswitch concepts and 3) demonstrating proof-of-conceptwith good stability, specificity, sensitivity and repeatability for continuousmonitoring in biological fluids (e.g., serum and blood). 

More Information

Selection process

For more information please contact Prof. dr. ir. Jeroen Lammertyn, tel.: +32 16 32 14 59, mail: jeroen.lammertyn@kuleuven.be or Mrs. Dragana Spasic, tel.: +32 16 37 71 18, mail: dragana.spasic@kuleuven.be.
You can apply for this job no later than 31/05/2021 via the online application tool

Web site for additional job details

Map Information

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Work location(s)
1 position(s) available at
Katholieke Universiteit te Leuven
Belgium
Leuven
3000

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EURAXESS offer ID: 633671

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