22/04/2021

PhD : mechanics of living cells

This job offer has expired


  • ORGANISATION/COMPANY
    Université Grenoble Alpes
  • RESEARCH FIELD
    EngineeringMechanical engineering
    PhysicsBiophysics
    PhysicsComputational physics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    22/05/2021 21:00 - Europe/Brussels
  • LOCATION
    France › Grenoble
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2021

OFFER DESCRIPTION

Living droplets : cell spreading as a wetting problem

The shape assumed by living cells plays a major role in its physiological function. As a cell spreads on a flat substrate, it takes a shape which is only partly reminiscent of the one of a liquid droplet. Indeed, the surface concavity reverses from convex to concave close to the triple line that it forms with the substrate. This change of curvature sign is a key information about the mechanical balance that governs cell shape. It is known that this balance is mostly between forces exerted within a thin material layer at the cell surface, made of a polymeric network and called the actin cortex. Within this cortex, motor-molecules of myosin generate a mechanical tension that can be modelled as a surface tension. This brings forward the comparison with the case of liquid droplets. However, the reversal of curvature sign indicates that one or more additional phenomena are at play and modify cell balance. We have already acquired experimental observations and quantifications that open the way to tackling this problem, first in the quasistatic case and then in the dynamic case. Solving it will allow us to understand the mechanisms that determine cell shape.

This PhD offer is fully funded for 3 years, which is the standard duration of a PhD project in France.

More Information

Benefits

Basic health and unemployment insurance is included. It is usual in France to purchase a complementary insurance costing about one or two percent of real earnings.

Web site for additional job details

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Physics: Master Degree or equivalent
    Engineering: Master Degree or equivalent
    Mathematics: Master Degree or equivalent

Skills/Qualifications

• Theoretical mechanics : elasticity, fluid mechanics, optionally visco-elasticity

• Numerics : finite differences, finite volumes or finite elements

• Coding : python or other language appropriate for scientific computation (C++, matlab, Julia,…)

• Good communication skills and motivation for an interdisciplinary project.

Work location(s)
1 position(s) available at
Université Grenoble Alpes
France
Grenoble
140, rue de la physique, Domaine Universitaire de St-Martin-d-Hères

EURAXESS offer ID: 632033

Disclaimer:

The responsibility for the jobs published on this website, including the job description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.

 

Please contact support@euraxess.org if you wish to download all jobs in XML.