ORGANISATION/COMPANYLausanne University Hospital and University of Lausanne
RESEARCH FIELDBiological sciences › Other
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE16/05/2021 21:00 - Europe/Athens
LOCATIONSwitzerland › Epalinges
TYPE OF CONTRACTTo be defined
HOURS PER WEEK42
OFFER STARTING DATE01/06/2021
Targeting Pathway Vulnerabilities Induced by Epigenetic Disturbance in Glioblastoma
The laboratory works at the interphase of basic and clinical research in brain tumors. In the proposed project, we aim at identifying druggable vulnerabilities of cancer relevant pathways revealed upon disturbing the tumor cells by epigenetic drugs, such as Bromodomain inhibitors (BETi). BETi target chromatin readers such as BRD4 that regulate expression of proto-oncogenic genes. We have identified several gene signatures indicative of cancer relevant pathways that are disturbed upon treatment with BETi. Investigating the function of these genes/pathways mechanistically in in vitro models and with bio-informatics approaches, will inform on their suitability to serve, as targets for treatment and the biological function will guide the choice for the second drug to use. Hits will be tested for synergistic effects with BET inhibition. Successful combinations will be taken into patient derived orthotopic xenograft models in the mouse. Molecular biomarkers and magnetic resonance imaging/ spectroscopy based response markers will be developed for translation into the clinical setting. 1,2 3
1. Gusyatiner O, Hegi ME. Glioma epigenetics: From subclassification to novel treatment options. Semin Cancer Biol. 2018; 51:50-58.
2. Gusyatiner O, Pham MDT, Lei Y, et al. BET inhibitors synergize with HDAC inhibitors and downregulate expression of interferon response genes in glioblastoma. In: AACR, ed. 109th Annual Meeting of the American Association for Cancer Research, Abstr #2923. Vol 78. Chicago, Illinois: AACR; 2018.
3. Stathis A, Bertoni F. BET proteins as targets for anticancer treatment. Cancer Discov. 2018; 8(1):24-36.
- PhD program Immunology and Cancer of the University of Lausanne (upon successful selection)
- Participation in programs of the Swiss Cancer Center Léman
Name & email of 2 referees
REQUIRED EDUCATION LEVELBiological sciences: Master Degree or equivalent
We are looking for a highly motivated student with interest in cancer biology and genetics who would like to make a difference
- Basic molecular biology techniques, (quantitative PCR, Western, etc)
- Cell culture
- Basic skills and interest in bioinformatics (R statistic language)
- Willingness to work with animals (mice)
- Team player for collaborative projects
EURAXESS offer ID: 629848
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