ORGANISATION/COMPANYUniversity of East Anglia
RESEARCH FIELDBiological sciences › OtherChemistry › Analytical chemistryChemistry › Organic chemistryChemistry › OtherPharmacological sciences › Pharmacy
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE21/05/2021 23:00 - Europe/London
LOCATIONUnited Kingdom › Norwich
TYPE OF CONTRACTOther
OFFER STARTING DATE01/10/2021
Natural products are a superb source of antibiotic molecules and offer a significant opportunity to overcome antimicrobial resistance (AMR) as either new antibacterials or modulators of resistance. One of the main ways in which bacteria can become resistant to antimicrobial agents is through acquisition of exogenous DNA, principally plasmids, containing AMR and virulence genes. Inhibition of plasmid conjugation therefore has significant potential to prevent the propagation of AMR within microbial populations. Research for conjugation inhibitors could also reduce pathogenicity by reducing the spread of virulence factors.
We have identified extracts from plants from Borneo that have antiplasmid activities. In this project, we will isolate the compounds that are responsible for this activity using bioassay-guided isolation, determine their structure by NMR spectroscopy and mass spectrometry and test them against clinically-relevant bacteria.
During this project you will gain skills in natural product chemistry, microbiology, and bioassay-guided isolation. You will work in a dedicated group of scientists interested in exploring natural products as potential antimicrobials, especially as anti-plasmid transfer agents.
Candidates should have a degree in Chemistry or Pharmacy with a high interest in natural product and analytical chemistry.
This PhD studentship is funded by the University of East Anglia. Funding is available to and applications are welcomed from UK candidates only. Funding comprises home tuition fees and an annual stipend of £15,609 (for a maximum of 36 months).
Acceptable first degree 2:1 Chemistry or Pharmacy.
EURAXESS offer ID: 629571
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