Postdoctoral Researcher in Laboratory of RNA Biology

Scientific discipline:

Molecular biology, biochemistry, genetics.

Job type (employment contract/stipend):

Full-time position, fixed-term contract

Remuneration/stipend amount/month:

8 900,00 – 11 650,00 PLN gross, depending on experience

Position starts on:

1^st June 2021 or later upon mutual agreement

Maximum period of contract/stipend agreement:

31^st Oct 2022, with the possibility of extension

Institution:

"ReMedy" International Research Agenda Unit, IMol PAS

Project leader:

Agnieszka Chacińska and Magda Konarska, Directors of ReMedy.

Project title:

“Regenerative Mechanisms for Health”

Subproject: „Structure-function analysis of the spliceosome”

Laboratory of RNA Biology, Head: Prof. Magda Konarska

Project description:

We are interested in the function of the spliceosome, its dynamic changes during splicing, and possible in response to stress conditions. The spliceosomal catalytic center undergoes dynamic changes during the catalytic phase of splicing; these changes affect splicing catalysis, altering splicing fidelity and thus affecting alternative splicing patterns. Using recent cryo-EM information of yeast S. cerevisiae spliceosome as a model, we focus on substrate-spliceosome interactions at the catalytic center. These studies will lead to new approaches for modulating alternative splicing patterns. For more information, please contact Prof. Magda Konarska: m.konarska@imol.institute