ORGANISATION/COMPANYUniversity of Mons
RESEARCH FIELDBiological sciences › BiologyPhysics
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE31/05/2021 21:00 - Europe/Brussels
LOCATIONBelgium › MONS
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE01/07/2021
The Mechanobiology and Soft Matter group led by Prof Sylvain Gabriele at the University of Mons (Belgium) has an opening for a PhD student in the area of cell biophysics1-3. The project falls with the group’s focus on understanding how mechanical cues from the matrix influence the structure and function of epithelial cells. In collaboration with the Hannezo’s group (IST, Austria), we have recently shown that the substrate curvature leads to thickness modulation of the epithelial monolayer and affects significantly nuclear shape and function4. We believe that these findings open new avenues for studying how mechanical and chemical signaling at the cellular and multicellular level can be modulated by the physico-chemical properties of the matrix (i.e. stiffness, curvature, etc.). The goal of this research project is to study how the long-distance transmission of signal-regulated kinase (ERK) waves can be regulated by the matrix curvature by combining our recent findings4 and the collaborative works of Hannezo and Hirashima (Kyoto University, Japan)5,6 groups.
This project will be conducted in a highly interdisciplinary environment and will involved extensive collaborations with the Hirashima’s group (experimental aspects) and Hannezo’s group (theoretical aspects).
1- D. Mohammed et al. Innovative tools for mechanobiology: unraveling outside-in and inside-out mechanotransduction Frontiers in Bioengineering and Biotechnology 7, 162 (2019)
2- D. Mohammed et al. Substrate area confinement is a key determinant of cell velocity in collective migration Nature Physics 15, 858-866 (2019)
3- M. Versaevel et al. Collective migration during a gap closure in a two-dimensional haptotactic model Scientific Reports 11, 1-11 (2021)
4- M. Luciano et al. Large-scale curvature sensing by epithelial monolayers depends on active cell mechanics and nuclear mechanoadaptation BioRxiv https://www.biorxiv.org/content/10.1101/2020.07.04.187468v1
5- D. Boocok et al. Theory of mechanochemical patterning and optimal migration in cell monolayers Nature Physics 17, 267-274 (2021)
6- N. Hino et al. ERK-mediated mechanochemical waves direct collective cell polarization Developmental Cell 53, 646-660 (2020)
We are looking for a motivated, curious and autonomous candidate, eager to work in an interdisciplinary environment to perform a PhD in physico-chemistry for life sciences and cell biophysics. The ideal candidate would have an experimental training in cell biophysics and/or bioengineering, with experience in microfabrication techniques and cell culture. Experience in soft matter physics, image and data analysis is also desirable.
- The position is secured for 4 years and granted by the EPIFORCE project of the National Fund for Fundamental Research (F.R.S-FNRS)
- The salary is approximately 2000 €/month (must be defined based on the candidate’s CV)
- Preferred start date: 1st July 2021
- For inquiries, please contact Sylvain Gabriele: email@example.com
- Lab website: http://www.umons.ac.be/influx/sgabriele
REQUIRED EDUCATION LEVELBiological sciences: Master Degree or equivalentPhysics: Master Degree or equivalent
REQUIRED LANGUAGESENGLISH: ExcellentFRENCH: Good
We are looking for a motivated, curious and autonomous candidate, eager to work in an interdisciplinary environment to perform a PhD in physico-chemistry for life sciences and cell biophysics. The ideal candidate would have an experimental training in cell biophysics and/or bioengineering, with experience in microfabrication techniques and cell culture. Experience in soft matter physics, image and data analysis is also desirable. A particular attention will be paid to the Master Thesis which must be provided in pdf and performed in the research field (cell biophysics, mechanobiology or physico-chemistry for life sciences).
EURAXESS offer ID: 626180
The responsibility for the jobs published on this website, including the job description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.
Please contact firstname.lastname@example.org if you wish to download all jobs in XML.