08/04/2021
European Research Council

PhD candidate

This job offer has expired


  • ORGANISATION/COMPANY
    University of Patras
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    17/05/2021 14:00 - Europe/Athens
  • LOCATION
    Greece › Rio
  • TYPE OF CONTRACT
    To be defined
  • JOB STATUS
    Other
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / ERC

OFFER DESCRIPTION

We are looking for a highly motivated PhD candidate with a background in cell and molecular biology to work in a dynamic and highly collaborative environment. Our lab is interested in understanding molecular pathways that safeguard genome stability and how their deregulation results in cancer development. We are particularly interested in how cells recognize and repair lesions within genomically unstable loci and the signalling pathways involved in the organization of the localized DNA damage response.

The PhD student will work on the ERC-funded program «NUCDDR-Nucleolar Responses to DNA damage: Nucleolus a rising hub of genome instability». The PhD student will undertake a project in the characterization of novel factors in the Nucleolar DNA damage response using super resolution microscopy and mass spectrometry methodologies.

Related publications:

Pefani, D.E, Tognoli, M.L., Pirincci Ercan, D., Gorgoulis, V., and O'Neill, E. (2018). MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B. The EMBO journal 37.

Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, van der Weyden L, Esashi F, Hammond EM, O'Neill E (2014) RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2. Nature Cell Biology 16: 962-971, 961-968.

Pefani DE, Pankova D, Abraham GA, Grawenda AA, Vlahov N, Scrace S and O’Neill E (2016). TGFβ targets the Hippo pathway scaffold RASSF1A to facilitate YAP/SMAD2 nuclear translocation. Molecular Cell 63: 156-166.

A BSc/MSc in Biomedical Sciences is required.

Previous experience in cell and molecular biology as well as a background in cell signaling and/or the DNA damage response would be an advantage.

More info can be found at https://ddrlab.upatras.gr/

For inquires please contact dpefani@upatras.gr

To apply for the post please send your CV, motivation and names for two referees at dpefani@upatras.gr

Application deadline: 17th May 2021

More Information

Additional comments

For inquires please contact: dpefani@upatras.gr

 

To apply for the post please send your CV, motivation and names for two referees at: dpefani@upatras.gr

Web site for additional job details

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Other: PhD or equivalent

Skills/Qualifications

A BSc/MSc in Biomedical Sciences is required.

 

Specific Requirements

Previous experience in cell and molecular biology as well as a background in cell signaling and/or the DNA damage response would be an advantage.

Work location(s)
1 position(s) available at
University of Patras / School of Medicine / Molecular Cell Biology Unit
Greece
Achaia
Rio
26504
University Campus

EURAXESS offer ID: 625406

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