08/04/2021
The Human Resources Strategy for Researchers

Phd contract in the field of Engineering financed for three years by the University of Clermont Auvergne

This job offer has expired


  • ORGANISATION/COMPANY
    Université Clermont Auvergne
  • RESEARCH FIELD
    Engineering
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    10/05/2021 00:00 - Europe/Brussels
  • LOCATION
    France › Aubière
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2021
  • REFERENCE NUMBER
    SPI-CD-2021-012

OFFER DESCRIPTION

Modeling blood flow using porous media hydro-mechanic

Curing patient suffering from liver diseases can require medic injections, resections and for end stage transplantations. For these cases, knowing blood circulation can maximize the effectiveness and lowering the risks.Blood circulation in the liver is quite complex and unique in human body. Indeed,this organ is the only one having a dual blood supply: hepatic portal vein, which represents around 80% of blood flux with blood mainly deoxygenated and rich in nutrients; the other vessel is the hepatic artery supplying liver with fully oxygenated blood.The blood flows through the liver to the hepatic vein (Bonfiglio et al. 2010). Hepatic portal vein, hepatic artery and hepatic vein divide into smaller and smaller vessels to form vascular trees; their extremities, named sinusoids, have a size of less than 10μm. At microscopic scale, this terminal generation is often described using structural units called lobules.Modelling of blood flow knowing these vascular trees was intensively studied (Debbaut et al. 2011). But MRI and CT scans do not allow to visualize small vessels like sinusoids. Two ways have been developed to model the blood flow in sinusoids: creating the end of the vascular tree using algorithms and applying standard methods to study blood flow or electric analogy (Debbaut et al. 2011, Van Der Plaats 2005). The second way is to consider sinusoids as porous media. For this method, models do not need to have the exact geometry of sinusoids, global parameters as permeability are enough.This second methodology seems promising as shown by (Bonfiglioet al. 2010, Debbaut et al. 2014) but lot of parameters still need to be studied.The objective of the proposed PhD thesis is to develop a new model based on porous media hydro-mechanical coupling, to describe 3D blood behaviour in lobules that can be then introduced into models using specific patient liver vessel geometries.

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Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Engineering: Master Degree or equivalent
Work location(s)
1 position(s) available at
The Pascal Institut (IP)
France
Région Auvergne Rhône-Alpes
Aubière
63178
Campus Universitaire des Cézeaux, TSA 60026, CS 60026, 4 Avenue Blaise Pascal

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EURAXESS offer ID: 625360

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