Phd contract in the field of Medical sciences financed for three years by the University of Clermont Auvergne

Impact of human adipose mitochondria during human body composition changes related to chronic diseases

Mitochondria play a key role in maintaining the energy homeostasis of tissues even adipose tissues.Quantitative (number of mitochondria) or qualitative mitochondrial dysfunctions on human skeletal muscle tissue have been well studied but studies on adipose tissue mitochondria are less documented, especially the differential potential impact ofthe origin and location (subcutaneous or visceral epiploic adipose tissue).Mitochondrial dysfunction in adipocytes is increasingly suggested to have strong correlation with metabolic diseases, including obesity and type 2 diabetes(body fat increase)or cancer (body fat decrease).The hypothesis is that thedysfunction of mitochondria results in detrimental effects on adipocyte differentiation, lipid metabolism, insulin sensitivity, oxidative capacity, and thermogenesis, which consequently leadsto metabolic diseases.The aim of this project is to characterize the mitochondrial function of subcutaneous adipose tissue and visceral adipose tissue frompatients with metabolic diseases, and thus to understand the effectof weightgain or weight loss on metabolic rateof these tissues. The study of the crosstalk between adipose tissue and skeletal muscle in this context of chronic diseasescould be also considered.

Touron J et al (2021) Aerobic Metabolic Adaptations in Endurance Eccentric Exercise and Training: From Whole Body to Mitochondria. Front Physiol. 2021 Jan 27;11:596351