07/04/2021
The Human Resources Strategy for Researchers

Phd contract in the field of Medical sciences financed for three years by the University of Clermont Auvergne

This job offer has expired


  • ORGANISATION/COMPANY
    Université Clermont Auvergne
  • RESEARCH FIELD
    Medical sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    23/06/2021 12:00 - Europe/Brussels
  • LOCATION
    France › Clermont-Ferrand
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2021
  • REFERENCE NUMBER
    SVSAE-CD-2021-047

OFFER DESCRIPTION

Interindividual variation in the metabolism of dietary polyphenols: determinants andimpact

Compelling evidence indicates that intakeof some polyphenolshas cardiometabolic health benefits. However, a high interindividual variation exist,which may be attributed to between-subjects differences in thecapacity to absorb and metabolize polyphenols. The project aims at improving our understanding of the interindividual variation in themetabolism of various polyphenolsand at identifying new metabotypes (groups of individuals sharing similar metabolic capacities). The stratification of subjects in metabotypes will allow to i) identify the main factors (age, sex, gut microbiota, genotype, dietary habits...) that determine their capacity to produce or not some bioactive metabolites, and ii)to relate the metabotypes with the effects observed on vascular health outcomesafter polyphenol intake. Considering the key role of the gut microbiota in polyphenol metabolism, its contribution to the interindividual variation will be investigatedin particular. Metabotypes will be identified based on comprehensive profiles of polyphenol metabolites measured in biofluids by targeted and untargeted mass-spectrometry-based metabolomics, after standardized intake of polyphenol sources in large intervention studies ( >200 subjects). This project is part of the EU-JPI FoodPhyt coordinated by the team. The work will also be supported by another project funded by the industry and possibly by2 other projects still under evaluation.

Manach, et al.(2017). Addressing the inter-individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction. Mol Nutr Food Res. Jun;61(6).

More Information

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Medical sciences: Master Degree or equivalent
Work location(s)
1 position(s) available at
Human Nutrition Unit (UNH)
France
Région Auvergne Rhône-Alpes
Clermont-Ferrand
63001
UFR de Médecine, 28 Place Henri Dunant, TSA 50400

Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R)

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EURAXESS offer ID: 624871

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