06/04/2021
The Human Resources Strategy for Researchers

Phd contract in the field of Medical sciences financed for three years by the University of Clermont Auvergne

This job offer has expired


  • ORGANISATION/COMPANY
    Université Clermont Auvergne
  • RESEARCH FIELD
    Medical sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    23/06/2021 12:00 - Europe/Brussels
  • LOCATION
    France › Clermont-Ferrand
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2021
  • REFERENCE NUMBER
    SVSAE-CD-2021-011

OFFER DESCRIPTION

Role of GH1 domain proteins in chromatin organization and transcription in Arabidopsis thaliana

Chromatin is a flexible structure that regulateseukaryotic genome expression in response to developmental and environmental signals. The spatiotemporal control of developmental gene expression depends in particular on the balance between deposition and eviction of the repressive mark K27me3 on histone H3 at the regulatory regions of target genes. The deposition of this mark is ensured by the polycombcomplex PRC2. The recruitment and activity of the PRC2 complex is fine-tunedby many factors including GH1-domain proteins that,in plants, can be classedin three distinct families: histone H1s, TRBs and GH1-HMGAs. Solidpreliminary data indicate that several proteins belonging to these three families are actively involved in the regulation of H3K27me3 mark deposition. In this project, we willstudy how these proteins act on chromatin organization and influence the deposition and eviction of the H3K27me3 mark thereby contributingtoPRC2-regulated gene transcription.

1-Teano G et al.(2021) Histone H1 protects telomeric repeats from H3K27me3 invasion inArabidopsis.BioRxivdoi.org/10.1101/2020.11.28.402172.

2-CharbonnelC et al. (2018), The Linker Histone GH1-HMGA1 Is Involved in Telomere Stability and DNA Damage Repair.Plant Physiol.177(1):311-327.

More Information

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Medical sciences: Master Degree or equivalent
Work location(s)
1 position(s) available at
Laboratory of Genetics, Reproduction and Development (GRED)
France
Région Auvergne Rhône-Alpes
Clermont-Ferrand
63001
Faculté de Médecine, 28 place Henri Dunant, BP 38

Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R)

Know more about it at Université Clermont Auvergne

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EURAXESS offer ID: 624592

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