06/04/2021
The Human Resources Strategy for Researchers

Phd contract in the field of Medical sciences financed for three years by the University of Clermont Auvergne

This job offer has expired


  • ORGANISATION/COMPANY
    Université Clermont Auvergne
  • RESEARCH FIELD
    Medical sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    23/06/2021 12:00 - Europe/Brussels
  • LOCATION
    France › Clermont-Ferrand
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2021
  • REFERENCE NUMBER
    SVSAE-CD-2021-009

OFFER DESCRIPTION

Characterisation of the mechanisms of regulation of myogenesis by the epigenetic enzyme TET

The development of the adult muscular system is a tightly regulated process which requires the coordinated deployment of a specific gene expression program. Accordingly, alterations in myogenic genes transcription and modifications of the epigenetic landscape underlie the aetiology of numerous neuromuscular disorders such as muscular dystrophies in humans. We gathered strong preliminary results showing that Drosophila TET, which codes for an epigenetic enzyme conserved in mammals,is required for proper gene expression in adult muscle progenitors and that it controls flight muscle development and function. Here, we propose to take advantage of the genetic tools available in Drosophila to tackle more precisely the role and mode of action of TET in muscle progenitor maintenance and differentiation.The PhD studentwill use a combination of state-of-the-art genetic, molecular, imaging techniques and behavioural assays to characterise TET function at different steps of their development: (1) in the larval AMPs, (2) in their differentiating progenies during pupariation, and (3) in differentiated adult muscles as well as in the recently described “satellite-like”muscle stem cells.

Rodrigues et al., Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood cell progenitors. eLife (2021) 10:e61409.

Fauquier et al.,CBP and p300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity. Scientific Reports (2018) Aug 22;8(1):12629.

More Information

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Medical sciences: Master Degree or equivalent
Work location(s)
1 position(s) available at
Laboratory of Genetics, Reproduction and Development (GRED)
France
Région Auvergne Rhône-Alpes
Clermont-Ferrand
63001
Faculté de Médecine, 28 place Henri Dunant, BP 38

Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R)

Know more about it at Université Clermont Auvergne

Know more about OTM-R

EURAXESS offer ID: 624590

Disclaimer:

The responsibility for the jobs published on this website, including the job description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.

 

Please contact support@euraxess.org if you wish to download all jobs in XML.