06/04/2021
The Human Resources Strategy for Researchers

Phd contract in the field of Medical sciences financed for three years by the University of Clermont Auvergne

This job offer has expired


  • ORGANISATION/COMPANY
    Université Clermont Auvergne
  • RESEARCH FIELD
    Medical sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    23/06/2021 12:00 - Europe/Brussels
  • LOCATION
    France › Clermont-Ferrand
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2021
  • REFERENCE NUMBER
    SVSAE-CD-2021-006

OFFER DESCRIPTION

Functional characterization of a new variant of the bile acid nuclear receptor FXRα by in vitro and in vivo approaches.

The nuclear bile acid receptor FXRα acts as an inducible transcription factor whose function isinvolved in the regulation of liver activity through its action on bile acid, carbohydrate and lipid metabolism. To date, the four described forms of FXRα that arise from splicing of transcripts produced from the two promoters of the NR1H4 gene differ in their tissue expression profile and target gene repertoires. These observations suggest an isoform-specific regulation of certain functions of FXRα which has become a potential therapeutic target in the treatment of many diseases since its loss of functionis often associated with metabolic disorders (steatosis, diabetes, obesity) and cancer development. Our recent work has identified a new splice variant of FXRα lacking half of its DNA binding domain which raises questions about its physical and functionalinteractions. The objective of the project is to explore the biological functions of this variant by incorporating its sequence into mouse hepatocytes in vivo, and then to study its molecular and genetic interactions using molecular biology and functionalgenomics approaches. These data will contribute to the evolution of the ongoing team's i-Site Emergence project, which will aim in its pursuit to discriminate the specificity of action of alternatively spliced variantsofFXRα.

Garciaet al. (2018) Nuclear receptor metabolism of bile acids and xenobiotics: a coordinated detoxification system with impact in health and diseases. Int J Mol Sci.19(11): 3630.

More Information

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Medical sciences: Master Degree or equivalent
Work location(s)
1 position(s) available at
Laboratory of Genetics, Reproduction and Development (GRED)
France
Région Auvergne Rhône-Alpes
Clermont-Ferrand
63001
Faculté de Médecine, 28 place Henri Dunant, BP 38

Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R)

Know more about it at Université Clermont Auvergne

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EURAXESS offer ID: 624581

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