ORGANISATION/COMPANYFundación Rioja Salud FRS
RESEARCH FIELDBiological sciences › BiologyMedical sciences › Veterinary medicine
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE06/06/2021 00:00 - Europe/Brussels
LOCATIONSpain › Logroño
TYPE OF CONTRACTTemporary
HOURS PER WEEK35
OFFER STARTING DATE15/08/2021
EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
MARIE CURIE GRANT AGREEMENT NUMBER956544
The PhD position is at the Oncology Unit of Fundación Rioja Salud (FRS), and within the framework of the Maria Skłodowska-Curie Innovative Training Network (MSCA-ITN) project “Directing the immune response through designed nanomaterials (DIRNANO)”.
The PhD student will focus on animal (mouse) models of vaccination, testing different vaccination strategies to be used as novel cancer therapies. The aims are:
- Develop xenograft and metastatic tumor models in immunocompetent mice.
- Test vaccines developed by other members of the consortium, characterizing and quantifying the specific antitumoral response.
The PhD student will be enrolled in the doctoral program at the University of La Rioja, Logroño, Spain. International collaboration is foreseen with the University of Newcastle (3-month secondment – on how to test complement activation), and at Oslo University (3-month secondment – on the evaluation of selective capture of nanoparticles by defined tumor associated macrophage phenotypes).
DIRNANO provides a highly integrated and interdisciplinary training of next-generation Early Stage Researchers (ESRs) at the interface of nanopharmaceutical bioengineering and its translation on preclinical and human immunology.
DIRNANO will develop biocompatible nanopharmaceuticals with either “super”-stealth or immune-specific behavior for cancer immunotherapy and vaccination by mapping nanoparticle-immune interactions through two core approaches: 1) inception of novel surface engineering approaches, based on new organic polymers, zwitterionic lipids, and conjugation chemistry strategies, 2) engineering of host or microbial-derived modulators of innate immunity (e.g. complement system).
DIRNANO team comprises internationally renowned scientists and industrialists at the forefront of nanoengineering, pharmaceutical sciences, molecular biosciences, commerce and business, thereby generating a unique pan-European macro-environment for interdisciplinary training of ESRs at the highest international level. Through participation of industrial partners, we will furnish ESRs with in-demand industrial and business skills, including process manufacturing, reproducibility and regulatory challenges, intellectual property and commercialization strategies.
DIRNANO will lead to rational engineering of broader libraries of NPs with tunable immune-modulating functions. The combinatorial analysis of new nanomaterial core-coat scaffolds will improve temporal and spatial understanding of biomaterial-innate immune interactions at the molecular level, thereby filling the void in overcoming adverse reactions to nanopharmaceuticals injection. DIRNANO will drive future development of small molecules and biologics-based nanopharmaceuticals through a “low-risk-high gain” perspective and within the context of personalized therapies and precision medicine. As such, DIRNANO will extensively contribute to European science, education and socioeconomics value, skill retention and brain-gain.
The salary for PhD students is based on the MSCA ITN Grant Agreement. The salary includes living allowances, mobility allowance, and family allowance, if eligible under the MSCA ITN rules.
Other benefits will be equal to all employees of Fundación Rioja Salud.
At the date of recruitment, the applicants for the MSCA fellowship must have no PhD and less than 4 years of full-time equivalent research experience from the award of the degree that entitles them to undertake a doctorate (either in the Country in which the degree was obtained or in the Country in which the applicant is to be recruited).
The applicants must not have resided or carried out their main activity (work, studies, etc.) in Spain for more than 12 months in the 3 years immediately before the recruitment date. Short stays, such as holidays, are not taken into account.
Applications will be reviewed as received. After the deadline, short-listed applicants complying with the requirements will be invited for a personal or telematic interview. All steps of the selection process will be published at the institutions webpage (https://www.fundacionriojasalud.org/gestion/rrhh/ofertas-empleo)
Applications must be submitted via email to: firstname.lastname@example.org
Applicants should provide the following information in their application in English:
1) Cover letter detailing your motivation and background for applying for the project.
2) A detailed CV including technical and analytical skills and publications, if applicable.
3) All academic level certificates (BSc and MSc) including university grades itemized by each course. A copy of the official permit to carry out animal experimentation, if available. Foreign documents should be sent as certified English translations.
4) A synopsis (abstract) of the BSc and MSc thesis, if applicable, or any previous research project.
5) At least, two professional referee letters (containing name, address, telephone, and email).
Web site for additional job details
REQUIRED EDUCATION LEVELBiological sciences: Master Degree or equivalentOther: Master Degree or equivalent
REQUIRED LANGUAGESENGLISH: Excellent
We are looking for a candidate with a MSc degree in biology, veterinary sciences, biochemistry, pharmacy, or similar biomedical degrees.
Candidates should have the ability to work independently and in collaboration with others, and have strong oral and written communication skills in English.
Experience with animal experimentation is expected, and having official permits for manipulating mice will be very positively valued.
Experience in histological techniques and flow cytometry will be useful.
Ability to enroll immediately will be requested.
EURAXESS offer ID: 624573
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