ORGANISATION/COMPANYRIKEN(The Institute of Physical and Chemical Research)
RESEARCH FIELDBiological sciencesComputer sciencePhysicsTechnology › Computer technology
RESEARCHER PROFILERecognised Researcher (R2)
APPLICATION DEADLINE19/03/2022 23:59 - Asia/Tokyo
LOCATIONJapan › Hyogo
TYPE OF CONTRACTTemporary
HOURS PER WEEKSee description
Laboratory for Epithelial Morphogenesis
RIKEN Center for Biosystems Dynamics Research
(Team Leader: Yu-Chiun Wang)
We investigate molecular and mechanical mechanisms underlying epithelial cell and tissue deformation using the early Drosophila embryo as the model system. We aim at a multiscale understanding of: 1) How cells interpret positional formation produced by the upstream gene regulatory network to execute mechanical programs of deformation; 2) how mechanical forces that alter cell shape are generated, transmitted across the cellular and tissue scale, and modulated by cell polarity, adhesion and cytoskeletal networks; 3) how morphological precision is achieved and has been evolved. The ongoing projects include:
1.Apical shape control via polarity-coupled microtubule pushing forces and counterbalancing cortical constraints.
2.Global compressive stress as a universal driving force for epithelial folding.
3.Tissue-scale mechanical coupling ensures morphogenetic precision.
4.Control of epithelial fold depth at the interface between adherens junctions and underlying actin.
5.Nucleus as the mechanical nexus and modulator of epithelial force transmission.
6.Mechanical and transcriptome analysis of epithelial flattening.
We employ, and engage in active development of, methods involving multiscale quantitative live imaging, optogenetics, and cell-type specific transcriptomics.
Key references: 1) Nature 484, 390.; 2) Developmental Cell 25, 299; 3) Nature Cell Biology 20, 36; 4) Developmental Cell 53, 212.For more detail on our research, please visit Laboratory for Epithelial Morphogenesis website.
[Job title and Job description]
Number of positions:
We work closely with the incoming Postdoctoral Researchers to develop an independent project, taking into account personal scientific interests, strengths and relevance to the general research theme of our lab. We encourage the applicant to propose unique, outside-the-box ideas, and identify areas of research and expertise s/he wishes to explore and learn in the lab.
Our lab is English-speaking, thus ideal for Japanese seeking to be trained under the international standards, or foreign nationals who wish to pursue a unique research experience that is both intellectually stimulating and culturally enriching. We value scientific audacity and creativity, and place strong emphasis on rigorous training to nurture future independent careers.
RIKEN Center for Biosystems Dynamics Research (Kobe Campus-East-West)
2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047 (Developmental Biology Buildings)
[Start of Employment]
As soon as possible (Negotiable)
Tissue morphogenesis,mechanical forces in development,cell polarity,physics of living systems
For details about "Salary and benefits", please refer to the above "Job posting URL".
Handling Personal Data:
EURAXESS offer ID: 622232
Posting organisation offer ID: D121031014
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