31/03/2021
The Human Resources Strategy for Researchers

Open postdoc position on developing a next-generation microfluidic platform for culturing complex 3D multicellular assemblies within the framework of the Materials-Driven Regeneration program

This job offer has expired


  • ORGANISATION/COMPANY
    Maastricht University (UM)
  • RESEARCH FIELD
    Medical sciences
  • RESEARCHER PROFILE
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    16/05/2021 23:59 - Europe/Brussels
  • LOCATION
    Netherlands › Maastricht
  • TYPE OF CONTRACT
    Temporary
  • HOURS PER WEEK
    40.0

OFFER DESCRIPTION

Job description:
At the Department of Instructive Biomaterials Engineering of the MERLN Institute for Technology-Inspired Regenerative Medicine at Maastricht University, and within the framework of the Materials-Driven Regeneration (MDR) program, we currently have a vacancy for a postdoc in the field of microfluidic three-dimensional (3D) cell culture platforms.

For developing regenerative medicine-based therapies, many in vitro research studies still rely on conventional, two-dimensional (2D) culture systems, which poorly recapitulate the complexity of the 3D (micro)environment of cells and tissues in vivo. Recent developments in 3D culture models rely on self-organization of (stem) cells towards 3D multicellular constructs such as organoids, with a complex tissue architecture and structure, and the ability to reflect the biological functions of tissues. Equipping such culture models with a controlled microenvironment for tissue development and advanced analytical/screening tools is one of the next foreseen challenges in this area. Within this postdoc project, we plan to computationally design and model, (micro)fabricate, and technically and biologically characterize microfluidic 3D cell culture platforms that allows the controlled formation and growth of 3D multicellular (polarized) assemblies such as organoids. The developed culture platform should allow the controlled provision of gradient patterns of soluble factors/biomolecules, and enable throughput screening and high-content imaging in conjunction with cell- or aggregate-level events as responses to the exposition to these factors.

About the MDR program:
The Research Center for MDR (https://mdrresearch.nl/) is a partnership between Eindhoven University of Technology, Maastricht University and Utrecht University, University Medical Center Utrecht and the Hubrecht Institute. This consortium was brought together to advance tissue and organ regeneration approaches with the use of instructive biomaterials The MDR Research Center was/is funded by the Ministry of Education, Culture and Science of The Netherlands in the framework of the Gravitation program. The interdisciplinary team of researchers within the MDR consortium aims to focus on the research and development of new, intelligent materials that stimulate the regeneration of damaged or diseased tissues and organs.

More Information

Benefits

We offer an interdisciplinary and collaborative postdoc project embedded into a highly international institute, which is one of the worldwide leading research institutions in the tissue regeneration field. Our modern laboratories include labs for biomaterials synthesis and characterization, biofabrication/‑printing, micro-/nanofabrication, microfluidics, cell culture, histology, molecular biology, imaging/microscopy, all provided with latest state-of-the-art equipment.

We offer a full-time temporary contract for a period of 3 years. The appointment will initially be for a period of 1 year and will be extended for another 2 years after positive evaluation. 
Depending on experience and qualification, the gross monthly salary is scale 10 (max. € 4.402,-).

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website www.maastrichtuniversity.nl > Support > UM employees.

Selection process

To apply for the above mentioned position, please submit a formal enquiry with the following documents:

  • Motivation letter;
  • Complete and detailed curriculum vitae with a list of all publications and the names of two people who can provide a recommendation;
  • Higher education certificates including (bachelor, master and PhD) diplomas and transcripts with courses taken and marks achieved;
  • Applicants who still need to graduate from their PhD should state the status of their thesis and approximate date of their PhD defense in the application.

You can send your application to: hrm-rw-vacatures@maastrichtuniversity.nl

Please mention also the vacancy number/job number AT20201.313 and the project name in your application.

Maastricht University is committed to nurturing an inclusive culture and a welcoming atmosphere. This inclusiveness strategy has resulted in a very diverse representation of nationalities and cultures. We strongly believe that diversity (including, but not limited to nationality, age and gender) of the staff and student population will increase the quality of UM education & research. Fostering diversity and inclusivity creates an academic community where individual talents thrive, and values and differences are cherished. We strongly encourage you to apply if you are qualified for this position.

Additional comments

For more information, you can contact one of the project supervisors:
·        Prof. Dr. Roman Truckenmüller (r.truckenmuller@maastrichtuniversity.nl)
·        Assist. Prof. Dr. Stefan Giselbrecht (s.giselbrecht@maastrichtuniversity.nl)
·        Prof. Dr. Pamela Habibović (p.habibovic@maastrichtuniversity.nl)
·        Dr. Niloofar Tahmasebi (z.tahmasebibirgani@maastrichtuniversity.nl)

Web site for additional job details

Offer Requirements

Specific Requirements

Your profile:
You should hold an MSc degree in bio(medical) engineering or similar, or in engineering with a corresponding major, and hold or about to obtain a PhD degree in (bio)microfluidics (including the related microfabrication) or similar. Strong interest, sound knowledge/understanding and hands-on experience in computer-aided design (CAD), finite element method (FEM; for example COMSOL Multiphysics®), including computational fluid dynamics (CFD), UV-/photolithography, soft-lithography, (thermoplastic) polymer microfabrication (particularly micromolding/‑replication and ‑joining, mechanical micromachining of polymers, and micro mold making), and the layout, fabrication, operation and characterization of microfluidic bioreactors or organ-on-chip devices based on porous culture membranes are essential for a successful conduction of the project. Having already worked in a micro-/nanofabrication clean room environment, and familiarity with 3D cell culture models is a plus. Good command of scientific English in terms of listening, speaking, reading and writing is indispensable. Experience with writing high-impact scientific papers must be demonstrated.

Work location(s)
1 position(s) available at
Maastricht University
Netherlands
Maastricht
6229 ER
Universiteitssingel 40

EURAXESS offer ID: 622158
Posting organisation offer ID: 299253

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