The Human Resources Strategy for Researchers

PhD Candidate for Department of Molecular Neurobiology

This job offer has expired

    Radboud University
    First Stage Researcher (R1)
    Recognised Researcher (R2)
    11/05/2021 00:00 - Europe/Brussels
    Netherlands › Nijmegen


Our lab combines Drosophila and mouse genetics to unravel molecular mechanisms underlying motor neurodegenerative diseases. One of the diseases that we focus on is Charcot-Marie-Tooth (CMT) peripheral neuropathy caused by mutations in tRNA synthetase genes. CMT is an incurable disease characterised by selective degeneration of peripheral motor and sensory axons, leading to progressive muscle weakness and wasting, and sensory dysfunction. Currently, no disease-modifying treatments are available for CMT, underscoring the need to gain better insight into the molecular mechanisms underlying this disease, a prerequisite for rational design of new drugs.
As a PhD candidate you will use Drosophila models for CMT caused by mutations in tRNA synthetases to unravel the molecular mechanisms underlying this disease. In addition to existing models, you will also generate and characterise novel knock-in Drosophila models, and investigate how defective mRNA translation can lead to selective degeneration of peripheral motor and sensory axons. You will become part of a multidisciplinary team, and have the opportunity to contribute to other ongoing projects at our lab. You will use a broad spectrum of methods and techniques including Drosophila genetics and behavioural analysis, fluorescence and confocal microscopy (and, if applicable, also super-resolution and electron microscopy), immunohistochemistry, molecular biology and biochemistry.

You will be given the opportunity to supervise Master's students. Beyond that, your exposure to teaching will be minimal.

More Information


  • Employment: 0.8 (5 year contract) - 1.0 FTE (4 year contract).
  • The gross starting salary amounts to €2,395 per month based on a 38-hour working week, and will increase to €3,061 from the fourth year onwards (salary scale P).
  • In addition to the salary: an 8% holiday allowance and an 8.3% end-of-year bonus.
  • Duration of the contract: You will be appointed for an initial period of 18 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 2.5 years (4 year contract) or 3.5 years (5 year contract).
  • The intended start date is 1 October 2021.
  • Your teaching load may be up to 10% of your appointment.
  • You will be able to use our Dual Career and Family Care Services. Our Dual Career and Family Care Officer can assist you with family-related support, help your partner or spouse prepare for the local labour market, provide customized support in their search for employment and help your family settle in Nijmegen.
  • Have a look at our excellent employment conditions. They include a good work-life balance (among other things because of the excellent leave arrangements), opportunities for development and a great pension scheme.

Selection process

Please address your application to Erik Storkebaum and submit it, using the application button, no later than 10 May 2021, 23:59 Amsterdam Time Zone.

Your application should include the following attachments:

  • Letter of motivation.
  • CV including contact information of at least two references.

Written applications will be evaluated, and selected applicants will be invited to a video interview. Finally, a further selection of applicants will be invited to a visit day, which will include an introduction to all lab members, one-to-one meetings with lab members, a tour of the laboratory facilities, an interview and a scientific presentation.

The first round of interviews will take place on 19 May 2021. The second round of interviews will take place on 23 June 2021.

Additional comments

For more information about this vacancy, please contact:
Erik Storkebaum, Professor, Head of Department
Tel.: +31 6 25 76 60 71
Email: e.storkebaum@donders.ru.nl

Web site for additional job details

Offer Requirements

Specific Requirements

  • You are a highly motivated, enthusiastic, critical, creative and team-oriented individual with a particular interest in neurobiology.
  • You hold a Master's degree (or are about to obtain one) in biology, biomedical sciences, biochemistry, genetics or a related discipline, and are interested in a scientific career.
  • Previous experience with Drosophila genetics would be a plus but is not required.
  • We are a dynamic international lab, so a good command of English is essential.
  • You are capable of working in a team as well as independently.

Work location(s)
1 position(s) available at
Radboud University
6525 XZ
Houtlaan 4

EURAXESS offer ID: 620656
Posting organisation offer ID: 299083


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