26/03/2021

Post-doctoral position in cell biology/cellular microbiology

This job offer has expired


  • ORGANISATION/COMPANY
    Institut Pasteur
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    31/05/2021 23:00 - Europe/Brussels
  • LOCATION
    France › Paris
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2021

OFFER DESCRIPTION

Title: Biogenesis of a lysosome-related organelle and a parasitic vacuole : a crosstalk between skin pigmentation and bacterial infection

Chlamydia trachomatis is a human-adapted pathogen that develops exclusively inside a vacuolar compartment. The host lab has gathered evidence that these bacteria hijacked the trafficking machinery implicated in the formation of Lysosome-Related Organelles (LROs) to build their vacuole. LROs are organelles that share features with lysosomes, though being not degradative. Defects in LRO biogenesis are associated to a number of syndromic disorders , e.g. in skin pigmentation, blood coagulation, immune or lung functions. The main aim of the present project is to exploit the bacteria as a tool to delineate the membrane trafficking pathways needed for LRO biogenesis, and to identify molecules that interfere with this process, with potential application in drug development.

The project will be led in close collaboration with the laboratory of Graça Raposo at Institut Curie in Paris, that has international recognized expertise in LRO biogenesis and in different electron microscopical methods. The host team itself, at Institut Pasteur, has 20 years of expertise in the study of the interactions between the intracellular bacterium C. trachomatis and epithelial cells.

The project will use experimental approaches of cell biology and molecular biology with an emphasis on state-of-the-art optical and electron microscopy techniques

 

More Information

Benefits

The salary is funded for the first 12 months. The contract will be extended provided successful application to funding agencies for post-doctoral salary.

Eligibility criteria

Candidates must hold a PhD or equivalent.

Selection process

Send CV, contact phone + email of two referees, and motivation letter to A. Subtil.

Required Research Experiences

  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    4 - 10

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: PhD or equivalent

Skills/Qualifications

No particular skills are required, but a solid training in cell biology will be appreciated, in particular good autonomy in microscopy techniques.

Work location(s)
1 position(s) available at
Institut Pasteur
France
Paris
75015
25 rue Dr Roux

EURAXESS offer ID: 620345

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