15/03/2021

PhD in cellular and molecular biology

This job offer has expired


  • ORGANISATION/COMPANY
    University Grenoble Alpes
  • RESEARCH FIELD
    NeurosciencesNeurobiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    15/06/2021 00:00 - Europe/Athens
  • LOCATION
    France › La Tronche
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    01/10/2021

OFFER DESCRIPTION

The Humbert's team offers a 3 years position for a PhD candidate.

NSCs in the adult Rodent subventricular zone (SVZ) generate neurons throughout life. Neurogenesis persists in the adult Human brain with new interneurons, probably born in the nearby SVZ, adding to the striatum. Interestingly, striatal neurogenesis decreases in Huntington’s disease (HD) patients. HD is a fatal neurodegenerative disorder with an adult onset. An autosomal dominant mutation of the huntingtin gene (Hdh) is responsible for the symptoms. The mutation is an abnormal expansion of a polymorphic CAG repeat present on the exon 1 sequence of the gene leading to an abnormal polyglutamine stretch at the N-terminus of the huntingtin protein (HTT) that is toxic for cortical and striatal neurons. We hypothesize that mutant HTT (mHTT) decreases neurogenesis in the SVZ by accelerating aging in NSCs. There is evidence of accelerated aging in HD with decreased neurogenesis in HD mouse models. We propose to test our hypothesis using SVZ cells cultures and adult SVZ whole-mounts from murine models of HD. Understanding the regulation of NSCs in the SVZ will help to design new therapies to sustain neurogenesis in the old and diseased brain.

More Information

Benefits

This 3 years position is funded.

Eligibility criteria

The candidate will be selected according to her/his

- bachelor and master marks and ranking

- expertise in some of the techniques skills required

 

Selection process

The candidate applies only through the EDCSV plateform:

https://edcsv.univ-grenoble-alpes.fr/fr/menu-principal/la-these/candidat...

Eligible candidates will defend in front of a jury that will perform the final selection (June 2021).

 

Additional comments

The PhD student is expected to do the pratical work at the bench as well as to carry out the bibliographic work in the field.

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    FRENCH: Good

Skills/Qualifications

The candidate has a solid theoretical background in cell/molecular biology and cell/molecular neuroscience. Training periods in lab during her/his formation is highly appreciated. The student shows writing skills and has an analytical mind. The student can provide her/his bachelor and master mark statments and ranking.

Specific Requirements

A specific training in cell culture, western blot, immunocytochemistry, cryostat brain slices and immunohistochemistry is highly appreciated.

Work location(s)
1 position(s) available at
Grenoble Institute for Neurosciences
France
La Tronche
38700
Chemin Fortuné Ferrini

EURAXESS offer ID: 615855

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